Understanding biomolecular interactions of nanoparticles for engineering efficient biomedical materials and devices

了解纳米颗粒的生物分子相互作用，用于工程高效的生物医学材料和设备

• 批准号: DP140101888
• 负责人: Prof Irene Yarovsky
• 金额: $ 24.12万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101888
• 关键词: Understanding; biomolecular; interactions; nanoparticles; engineering

Recent studies suggest that proteins bind differently to nano-patterned materials. This phenomenon holds a great potential for engineering of novel materials and devices for biomedical applications. At the same time, there are increasing concerns due to formation of biomolecular "coronas" of nanoparticles which can change their biological identity. This project will develop knowledge of the molecular mechanisms of nanomaterials interactions with molecular components of biological environment which will be exploited to improve molecular recognition needed in biosensors and drug delivery applications. The project outcomes will help formulate rational design principles for efficient biomedical materials and nanodevices.

最近的研究表明，蛋白质与纳米图案材料的结合方式不同。这种现象为生物医学应用的新型材料和器件的工程设计提供了巨大的潜力。与此同时，由于纳米颗粒的生物分子“冠”的形成，其可以改变它们的生物特性，因此存在越来越多的关注。该项目将开发纳米材料与生物环境的分子组分相互作用的分子机制的知识，这些分子机制将用于改善生物传感器和药物递送应用中所需的分子识别。该项目的成果将有助于制定有效的生物医学材料和纳米器件的合理设计原则。