Growth of Epithelial Cells on Textured Surfaces

上皮细胞在纹理表面上的生长

• 批准号: 9060201
• 负责人: Edward Johnson
• 金额: $ 4.97万
• 依托单位: Spire Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-01 至 1991-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9060201&HistoricalAwards=false
• 关键词: Growth; Epithelial; Cells; Textured; Surfaces

The microscale physical topography, or microtexture, of biomaterial surfaces bears strongly on endothelial and soft tissue cell adhesion and growth on these surfaces. Ion beam surface texturing technology offers precise control of the size, shape, and density of micrometer scale texture features. A two stage project is suggested to investigate ion beam textured organic surfaces as substrates for epithelial cell growth. The first stage will investigate the role of surface texture in promoting growth of epithelial cells in culture, and establish a surface morphology which optimizes the rate at which epithelial cells plate out of solution onto this substrate. This technique may provide superior culture vessels for epithelial cells which are difficult to culture. The second stage will investigate the use of artificial texture on biomaterials to create an improved skin system for catastrophic burn victims.

微尺度的物理地形，或微观结构， 生物材料表面对内皮细胞和 软组织细胞在这些表面上粘附和生长。 离子束表面纹理技术提供精确的 千分尺的尺寸、形状和密度的控制 缩放纹理特征。 建议分两个阶段进行 研究离子束纹理有机表面， 上皮细胞生长的基质。 第一阶段 将研究表面纹理在促进 培养上皮细胞的生长，并建立一个 表面形态优化了 从溶液中析出的上皮细胞 衬底 该技术可提供上级培养 上皮细胞的血管， 文化 第二阶段将调查 在生物材料上添加人工纹理， 皮肤系统的灾难性烧伤受害者。