Growth of Epithelial Cells on Textured Surfaces

生物材料表面的微尺度物理地形或微纹理对内皮细胞和软组织细胞在这些表面的粘附和生长有很强的影响。离子束表面纹理技术可以精确控制微米尺度纹理特征的大小、形状和密度。建议分两个阶段研究离子束织构有机表面作为上皮细胞生长的底物。第一阶段将研究表面纹理在促进培养上皮细胞生长中的作用，并建立一种表面形态，以优化上皮细胞从溶液中板到该底物的速度。该技术可为难以培养的上皮细胞提供优良的培养血管。第二阶段将研究在生物材料上使用人造纹理，为灾难性烧伤患者创造一种改进的皮肤系统。

The microscale physical topography, or microtexture, of biomaterial surfaces bears strongly on endothelial and soft tissue cell adhesion and growth on these surfaces. Ion beam surface texturing technology offers precise control of the size, shape, and density of micrometer scale texture features. A two stage project is suggested to investigate ion beam textured organic surfaces as substrates for epithelial cell growth. The first stage will investigate the role of surface texture in promoting growth of epithelial cells in culture, and establish a surface morphology which optimizes the rate at which epithelial cells plate out of solution onto this substrate. This technique may provide superior culture vessels for epithelial cells which are difficult to culture. The second stage will investigate the use of artificial texture on biomaterials to create an improved skin system for catastrophic burn victims.