Defining the mechanism of assembly of herpes simplex virus in the neuronal growth cone and its subsequent exit to epithelial cells

定义单纯疱疹病毒在神经元生长锥中组装及其随后退出上皮细胞的机制

• 批准号: nhmrc : GNT1130512
• 负责人: Dr Monica Miranda Saksena
• 金额: $ 77.46万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-mechanism-assembly-epithelial-cells/1347814
• 关键词: Defining; mechanism; assembly; herpes; simplex

Herpes simplex virus (HSV) causes dormant infection of nerve cell bodies near the spine. It periodically reactivates to be transported along nerves to the skin where it causes oral, genital or neonatal herpes and mediates HIV superinfection. HSV assembles into its final form in the terminal part of the axon just prior to crossing into skin. Elucidating the mechanism of HSV assembly and exit will facilitate new strategies for antiviral agents and immune treatment for HSV and similar viruses.

单纯疱疹病毒(HSV)可引起脊柱附近神经细胞体的潜伏性感染。它会周期性地重新激活，沿着神经运输到皮肤，在那里它会引起口腔、生殖器或新生儿疱疹，并介导艾滋病毒的重叠感染。HSV在进入皮肤之前，在轴突的末端组装成其最终形式。阐明单纯疱疹病毒的组装和退出机制将为抗病毒药物和免疫治疗HSV及类似病毒提供新的策略。