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Preserving synaptic function following gene-silencing therapy in Huntington disease: mechanisms and specificity requirements

Preserving synaptic function following gene-silencing therapy in Huntington disease: mechanisms and specificity requirements
亨廷顿病基因沉默治疗后保留突触功能：机制和特异性要求
批准号：
390414
负责人：
Parsons Matthew P
金额：
$60.75万
依托单位：
Memorial University of Newfoundland
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-09-01 至 2023-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=390414&lang=en
关键词：
Antisense Oligonucleotide Electrophysiology Gene-Therapy Glutamate Huntington Disease Live-Imaging Synaptic Plasticity

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中文摘要
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英文摘要
Huntington disease (HD) is a fatal neurodegenerative disease characterized by debilitating motor, cognitive and psychiatric symptoms. HD has been described as having symptoms of ALS, Alzheimer's disease and Schizophrenia at the same time. There is no cure
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会议论文
Extracellular glutamate dynamics exhibit synapse asymmetry in Alzheimer disease
  • 批准号：
    468779
  • 项目类别：
    Operating Grants
  • 资助金额：
    $58.52万
  • 财政年份：
    2022
  • 负责人：
    Parsons Matthew P
  • 依托单位：
    Memorial University of Newfoundland
Potential roadblocks to Huntington disease therapy: Exploring the side effects of huntingtin knock-down on synaptic physiology
  • 批准号：
    301142
  • 项目类别：
    Fellowship Programs
  • 资助金额：
    $8.47万
  • 财政年份：
    2013
  • 负责人：
    Parsons Matthew P
  • 依托单位：
    University of British Columbia
海外基金