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Transgenic Models of Neuroendocrine Cell Differentiation

Transgenic Models of Neuroendocrine Cell Differentiation
神经内分泌细胞分化的转基因模型
批准号：
9108426
负责人：
Richard Allen
金额：
$13.5万
依托单位：
Oregon Health & Science University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1991
资助国家：
美国
项目状态：
已结题
起止时间：
1991-09-01 至 1994-08-31
来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9108426&HistoricalAwards=false
关键词：
TransgenicModelsNeuroendocrineCellDifferentiation

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英文摘要
A genetic approach will be taken to investigate cell specification in the embryonic pituitary. A transgenic mouse will be made in which expression of the thymidine kinase gene will be directed to melanotropes and corticotropes using the promoter of the pro-opiomelanocortin gene. Cells that express the transgene will be ablated and the consequences of this ablation on the differentiation of other pituitary cell types, repopulation of the pituitary with pro-opiomelanocortin cells and re-differentiation of the hypothalamic-pituitary axis will be determined. These studies offer an innovative, non-invasive approach toward understanding the role of cell-cell interactions in neural development and specification.
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MLTC-M Community of Practice in Statistical Methods for Multimorbidity Research
  • 批准号：
    MR/X004457/1
  • 项目类别：
    Research Grant
  • 资助金额：
    $5.01万
  • 财政年份：
    2022
  • 负责人：
    Richard Allen
  • 依托单位：
    University of Leicester
I-Corps: Crowdsource sensing of earthquakes
  • 批准号：
    1744819
  • 项目类别：
    Standard Grant
  • 资助金额：
    $5.0万
  • 财政年份：
    2017
  • 负责人：
    Richard Allen
  • 依托单位：
    University of California-Berkeley
Planning Grant: I/UCRC for Geoscience
  • 批准号：
    1362166
  • 项目类别：
    Standard Grant
  • 资助金额：
    $1.62万
  • 财政年份：
    2014
  • 负责人：
    Richard Allen
  • 依托单位：
    University of California-Berkeley
Prospects for Anglophone Studies: Comparing Indian and British Programmes and Methodologies
  • 批准号：
    AH/I023155/1
  • 项目类别：
    Research Grant
  • 资助金额：
    $4.59万
  • 财政年份：
    2011
  • 负责人：
    Richard Allen
  • 依托单位：
    The Open University
国内基金
海外基金
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