Regulation, Control and Design of Plant Root Systems for Production of Valuable Chemicals

生产有价值化学品的植物根系统的调节、控制和设计

• 批准号: 9110288
• 负责人: Hector Flores
• 金额: $ 58.22万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-15 至 1995-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9110288&HistoricalAwards=false
• 关键词: Regulation; Control; Design; Plant; Root

Roots in nature produce an astonishing variety of secondary metabolites, many of which have been used as pharmaceuticals, pesticides, flavors, fragrances, etc. A recent experimental system, "hairy root" cultures obtained by transformation with Agrobacterium rhizogenes, has been developed and become a useful tool for understanding basic root biology. The "hairy root" approach also has several advantages over other plant tissue culture systems for the production of plant chemicals: fast-growth as organized cultures, higher and stable yields of secondary metabolites, production of both intra- and extracellular metabolites, and direct amenability to genetic engineering. The goal of this proposal is to integrate expertise in the biological and engineering sciences towards the development of commercially viable plant root systems.

自然界中的根会产生种类惊人的次生代谢物，其中许多已被用作药物、杀虫剂、香精、香料等。一个最近的实验系统，“毛状根”由根农杆菌转化获得的培养物，已经发展成为了解基本根系生物学的有用工具。与其他植物组织培养系统相比，“毛状根”方法在生产植物化学物质方面也有几个优势：作为有组织培养物的快速生长，次生代谢物的产量更高且稳定，细胞内和细胞外代谢物的生产，以及直接适用于基因工程。该提案的目标是整合生物和工程科学方面的专业知识，以开发商业上可行的植物根系。