Regulation, Control and Design of Plant Root Systems for Production of Valuable Chemicals

自然界中的根产生了惊人的多样性， 次级代谢产物，其中许多已被用作 医药、农药、香精香料等 最近的实验系统，“毛状根”培养获得 通过用发根农杆菌转化， 发展并成为一个有用的工具， 根系生物学 “毛根”的做法也有几种 与其它植物组织培养系统相比， 植物化学品的生产：按组织结构迅速增长 培养，更高和稳定的产量， 代谢物，产生细胞内和细胞外 代谢物，以及对遗传的直接顺从性 工程. 该提案的目标是整合 生物和工程科学方面的专业知识 发展商业上可行的植物根 系统.

Roots in nature produce an astonishing variety of secondary metabolites, many of which have been used as pharmaceuticals, pesticides, flavors, fragrances, etc. A recent experimental system, "hairy root" cultures obtained by transformation with Agrobacterium rhizogenes, has been developed and become a useful tool for understanding basic root biology. The "hairy root" approach also has several advantages over other plant tissue culture systems for the production of plant chemicals: fast-growth as organized cultures, higher and stable yields of secondary metabolites, production of both intra- and extracellular metabolites, and direct amenability to genetic engineering. The goal of this proposal is to integrate expertise in the biological and engineering sciences towards the development of commercially viable plant root systems.