Spinal Control of Micturition

脊柱控制排尿

• 批准号: 9111207
• 负责人: William Collins
• 金额: $ 28.82万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9111207&HistoricalAwards=false
• 关键词: Spinal; Control; Micturition

Bladder function is controlled by spinal reflexes involving spinal motoneurons, which connect to muscles in the periphery, and interneurons, which make their connections within the central nervous system. The activity of these spinal neurons is coordinated by higher centers in the brain. The object of the present work by Drs. Collins and Erichsen is to identify and characterize these spinal motoneurons, both anatomically and physiologically. At present, little is known about these neurons, particularly the spinal interneurons; this lack of knowledge is the result of the inability to identfy function-specific spinal interneurons and to establish their connections within the spinal cord. Recently, the investigators of these studies have developed both the electrophysiological and neuroanatomical techniques which will enable them to achieve this objective. The use of a multidisciplinary approach in this research will allow a more comprehensive examination and analysis of individual spinal neurons than would be possible with any single technique. The information obtained from these experiments will provide an essential database of the locations, functional identities, and synaptic connections of spinal interneurons involved in the control of bladder function.

膀胱功能由脊髓反射控制， 脊髓运动神经元，连接到周围的肌肉， 和中间神经元，它们在中枢神经系统内建立联系， 神经系统这些脊髓神经元的活动 由大脑的高级中枢协调。的目的 柯林斯博士和埃里克森博士目前的工作是识别并 描述这些脊髓运动神经元，无论是解剖学和 生理上的。目前，人们对这些神经元知之甚少， 特别是脊髓中间神经元;这种知识的缺乏， 由于无法识别特定功能的脊柱 并在脊髓内建立它们的连接 线.最近，这些研究的调查人员已经开发出 电生理学和神经解剖学技术 这将使他们能够实现这一目标。的使用 这项研究的多学科方法将使更多的 个体脊柱综合检查分析 比任何一种技术都要复杂。的 从这些实验中获得的信息将提供一个 位置、功能标识的基本数据库， 脊髓中间神经元的突触连接参与 控制膀胱功能。