Functional role of anterior cingulate gyrus in the control of micturition reflex

排尿反射由复杂的中枢神经系统控制。此外，根据动物生理学和人类功能神经影像学研究，前扣带回（ACG）神经元可能在排尿控制中起重要作用。细胞外谷氨酸盐、血清素和多巴胺的水平通过高效液相色谱法进行分析。谷氨酸和多巴胺水平显着增加，在排尿反射引起的生理盐水输注，而血清素水平没有改变ACG。当输注乙酸时（膀胱炎状态），观察到谷氨酸水平显著升高。5-羟色胺水平也在这种过度膀胱大鼠模型中显著增加。ACG是将其投射发送到脑桥排尿中枢的高级脑区，脑桥排尿中枢是控制排尿反射的关键脑区。

The micturition reflex is controlled by a complex hierarchy of the central nervous system. Additionally, anterior cingulate gyrus (ACG) neurons could have an important role in micturition control based on animal physiological and human functional neuroimaging studies. Extracellular levels of glutamate, serotonin, and dopamine were analyzed by high-performance liquid chromatography. Glutamate and dopamine levels significantly increased during micturition reflex induced by saline infusion, whereas serotonin levels did not change in ACG. When acetic acid was infused (cystitis status), marked increases in glutamate levels were observed. Serotonin levels also significantly increased in such overatcivebladder rat model. ACG is a higher brain region that sends its projection to the pontine micturition center, which is a key brain region controlling the micturition reflex.