Functional role of anterior cingulate gyrus in the control of micturition reflex

排尿反射是由复杂的中枢神经系统控制的。此外，根据动物生理和人类功能神经影像学研究，前扣带回（ACG）神经元可能在排尿控制中起重要作用。高效液相色谱法分析细胞外谷氨酸、血清素和多巴胺水平。在生理盐水输注引起的排尿反射中，谷氨酸和多巴胺水平显著升高，而血清素水平在ACG中没有变化。当输注醋酸（膀胱炎状态）时，观察到谷氨酸水平显著升高。血清素水平在膀胱过度活动模型中也显著升高。ACG是一个高级脑区，将其投射到脑桥排尿中心，脑桥排尿中心是控制排尿反射的关键脑区。

The micturition reflex is controlled by a complex hierarchy of the central nervous system. Additionally, anterior cingulate gyrus (ACG) neurons could have an important role in micturition control based on animal physiological and human functional neuroimaging studies. Extracellular levels of glutamate, serotonin, and dopamine were analyzed by high-performance liquid chromatography. Glutamate and dopamine levels significantly increased during micturition reflex induced by saline infusion, whereas serotonin levels did not change in ACG. When acetic acid was infused (cystitis status), marked increases in glutamate levels were observed. Serotonin levels also significantly increased in such overatcivebladder rat model. ACG is a higher brain region that sends its projection to the pontine micturition center, which is a key brain region controlling the micturition reflex.