Progesterone and the Neural Mechanisms of Behavior

黄体酮和行为的神经机制

• 批准号: 9112777
• 负责人: Joseph DeBold
• 金额: $ 22.32万
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-15 至 1995-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9112777&HistoricalAwards=false
• 关键词: Progesterone; Neural; Mechanisms; Behavior

Progesterone is an important steroid hormone for regulating many aspects of physiology. It also has a number of effects on behavior. The research findings from Dr. DeBold's previous NSF grant showed that progesterone can affect behavior through direct action on two specific sites in the brain, one in the forebrain and one in the midbrain. The primary objective of the present award is to determine how progesterone acts at its target site in the midbrain to influence behavior. Steroid hormones generally exert their effects by entering cells, binding with a receptor inside the cell, and then the steroid-receptor complex acts on specific sites on the chromosomes to change the proteins that the cell synthesizes. This mechanism of action has been found in virtually every cell that responds to steroid hormones. In the midbrain, however, progesterone appears to have its effect through a different mechanism. A form of progesterone which cannot enter cells can be effective in the midbrain, although it is inactive elsewhere. The effect of progesterone on behaviorally-relevant actions via neuronal membranes will be tested. The specific protein which mediates this action will be determined. The proposed studies will demonstrate an alternative mechanism of action for one class of steroid hormones. This work will contribute to knowledge about how hormones act to regulate behavior.

孕酮是一种重要的类固醇激素， 生理学方面。它也有一些影响， 行为DeBold博士以前的NSF研究结果 格兰特指出，孕酮可以通过直接影响行为， 作用于大脑中的两个特定部位，一个在前脑， 一个在中脑目前的主要目标 奖励是为了确定孕酮如何在其靶位点发挥作用， 中脑来影响行为。类固醇激素一般 通过进入细胞，与受体结合， 然后类固醇受体复合物作用于 染色体上的特定位点来改变蛋白质， 细胞合成。这种作用机制已被发现， 几乎所有对类固醇激素有反应的细胞在 然而，中脑孕酮似乎有其作用， 通过不同的机制。一种黄体酮， 不能进入细胞可以在中脑有效，虽然它 在其他地方不活跃。孕酮对 通过神经元膜的行为相关的行动将是 测试.介导这种作用的特定蛋白质将是 测定拟议的研究将展示一种替代方案， 一类类固醇激素的作用机制。这项工作 将有助于了解激素是如何调节 行为