U.S.-Germany Collaborative Research in the Study of Alkyl Propargyl Biradicals

美德合作研究烷基炔丙基双自由基

• 批准号: 9113203
• 负责人: William Agosta
• 金额: $ 0.9万
• 依托单位: Rockefeller University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-15 至 1995-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9113203&HistoricalAwards=false
• 关键词: U.S.; Germany; Collaborative; Research; Study

This award supports Professor William C. Agosta of the Rockefeller University for continued collaboration in organic chemistry with Professor Paul Margaretha of the Instiute for Organic Chemistry of the University of Hamburg, Germany. Their joint research focuses on three problems in the chemistry of alkyl propargyl biradicals. One is a mechanistic study of the influence of spin state on the behavior of vinyl carbene intermediates. Another is an extension of their recently discovered (3+2) reaction between alkenes and 3-alkynyl-2-cycloalkenones to intramolecular systems. The final is an exploration of the photochemical cycloaddition of 2-alkynyl-2-cycloalkenones with alkenes, both inter- and intra-molecularly. The two laboratories have complementary strengths and characteristics. Professor Agosta's interests are in the design and synthesis of particular substrates to probe mechanisms and to search for new processes. His small group at The Rockefeller University is composed of postdoctoral workers. Professor Margaretha has particular expertise in chemical theory and radical theory. His research group in Hamburg is much larger than Professor Agosta's and is composed of doctoral students, which makes it better able to carry out studies requiring greater manpower. The long term goals of the above research are to understand better the conditions under which alkyl propargyl biradicals are formed and to define the mechanism of conversion of these biradicals to vinyl carbenes and from them to stable products. Professors Agosta and Margaretha discovered alkyl propargyl biradicals in 1981. Their current and proposed work all involve either new chemistry or novel mechanistic studies in this general area.

该奖项支持威廉C教授。阿戈斯塔 洛克菲勒大学继续合作，在有机 化学研究所的保罗·佩尔萨教授 德国汉堡大学有机化学系。 他们的 联合研究的重点是烷基化学中的三个问题 炔丙基双自由基 一个是对影响的机制研究 自旋态对乙烯基卡宾中间体行为的影响。 另一个是他们最近发现的（3+2）反应的扩展 在烯烃和3-炔基-2-环烯酮之间， 系统. 最后是光化学的探索 2-炔基-2-环烯酮与烯烃的环加成， 在分子间和分子内。 这两个实验室 互补的优势和特点。 阿戈斯塔教授 感兴趣的是特定底物的设计和合成， 探索机制，寻找新的工艺。 他的小 洛克菲勒大学的研究小组由博士后组成， 工人 埃克塞特教授在化学方面有着特殊的专长， 理论和激进理论。 他在汉堡的研究小组 比阿戈斯塔教授的大，由博士组成， 学生，这使得它能够更好地开展研究，需要 更多的人力。 上述研究的长期目标是更好地了解 烷基炔丙基双自由基形成的条件 并定义这些双自由基转化为 乙烯基卡宾并从它们到稳定的产物。 教授 阿戈斯塔和阿西塔发现了烷基炔丙基双自由基， 1981. 他们目前和拟议的工作都涉及新的 化学或新的机制研究在这个一般领域。