U.S.-Thailand Cooperative Research in Renal Function in Vertebrates

美国-泰国脊椎动物肾功能合作研究

• 批准号: 9113316
• 负责人: William Dantzler
• 金额: $ 2万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-15 至 1995-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9113316&HistoricalAwards=false
• 关键词: U.S.; Thailand; Cooperative; Research; Renal

This proposal requests funds to permit Dr. William H. Dantzler, Department of Physiology, University of Arizona, to pursue with Dr. Varanuj Chatsudthipong, Department of Physiology, Mahidol University, Thailand, for a period of 24 months, research on the renal tubular transport of organic anions. The studies will involve a continuation and expansion of work on organic anion transport steps at both the basolateral and luminal membranes of mammalian renal tubules. They will utilize isolated perfused and nonperfused renal tubules in vitro to test, in intact tubules, the model, based on data from membrane vesicles, that organic anions are transported into cells against an electrochemical gradient. They will utilize similar techniques to evaluate p-aminohippurate transport across the luminal membrane in intact tubules and evaluate possible anion exchange and the involvement of inorganic ions in this transport process. These studies are important in gaining an understanding of how kidneys function and in making a comparison of kidney function in reptiles and in mammals. This project adds an international cooperative dimension to the PI's research under NSF Grant No. DCB-9001985. The collaborators are highly respected scientists who have a record of successful prior cooperative research. This project is relevant to the objectives of the Science in Developing Countries Program which seeks to increase the level of cooperation between U.S. and developing country scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit.

本提案请求资助亚利桑那大学生理学系William H. Dantzler博士与泰国玛希隆大学生理学系Varanuj Chatsudthipong博士进行为期24个月的有机阴离子肾小管运输研究。这些研究将包括继续和扩大哺乳动物肾小管基底外膜和管腔膜上有机阴离子运输步骤的工作。他们将利用体外分离的灌注和非灌注肾小管来测试，在完整的小管中，基于膜泡数据的模型，有机阴离子被输送到细胞中，对抗电化学梯度。他们将利用类似的技术来评估对氨基马嘌呤在完整小管中穿过管腔膜的运输，并评估可能的阴离子交换和无机离子在这一运输过程中的参与。这些研究对于了解肾脏的功能以及比较爬行动物和哺乳动物的肾脏功能非常重要。该项目在美国国家科学基金（NSF）资助下为PI的研究增加了一个国际合作的维度。dcb - 9001985。合作者是备受尊敬的科学家，他们之前有成功的合作研究记录。该项目与发展中国家科学项目的目标相关，该项目旨在通过科学信息、思想、技能和技术的交流以及在互利问题上的合作，提高美国和发展中国家科学家和工程师之间的合作水平。