Acquisition of a Differential Scanning Calorimeter

我们正在申请差示扫描量热仪（ DSC），配备了扩展的温度范围（220 ℃）， 外冷机组，数据采集分析系统 软件和可重复使用的细胞。 这是唯一一个 所需的灵敏度和温度范围。 购买这台仪器将使P.I.年代到 分析酶的热变性特性 从嗜热和超嗜热的生物中， 小分子热变性的分子机理 已知结构的蛋白质，分析热力学基础 蛋白酶抑制剂的作用， 意义，并探讨亚基和 结构域相互作用在酶活性产生中的作用。 这些研究将扩展我们对结构的认识， 蛋白质的热稳定性和 内切酶

We are requesting for a differential scanning calorimeter ( DSC) equipped with extended temperature range (220C), an external cooling unit, data collection and analysis system and software and reusable cells. This is the only DSC with the requisite sensitivity and temperature range offered. The acquisition of this instrument will permit the P.I.'s to analyze the thermal denaturation characteristics of enzymes from thermophilic and superthermophillic organisms, to study the molecular mechanism of thermal denaturation of small proteins of know structure, to analyze thermodynamic basis of action of a protease inhibitor of physiological significance and to explore the significance of subunit and domain interactions in producing activity in an enzyme. These studies will extend our knowledge of the structural basis of thermal stability in proteins and activity in enzymes.