MRI: Acquisition of an Isothermal Titration Calorimeter and a Differential Scanning Calorimeter

MRI：获取等温滴定量热计和差示扫描量热计

• 批准号: 0723278
• 负责人: Daryl Eggers
• 金额: $ 18.35万
• 依托单位: San Jose State University Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0723278&HistoricalAwards=false
• 关键词: MRI; Acquisition; Isothermal; Titration; Calorimeter

San Jose State University will acquire an isothermal titration calorimeter and a differential scanning calorimeter with this award from the Major Research Instrumentation program. The instruments will enable researchers at the San Jose State University, San Francisco State University, Santa Clara University and Sonoma State University to investigate the thermodynamics of protein hydration, determinants in binding vitamin D receptor, mechanistic studies of the styrene catabolic pathway, metal binding properties of advanced glycation end products, and biophysical characterization of the interaction of bacteriocins with model membranes. Calorimeters measure the heat changes occurring during chemical and biochemical reactions or when materials decompose or undergo a phase change. This provides thermodynamic data which help to understand what is happening at the molecular level. The calorimeters will be used by undergraduates in their research work. They will be incorporated into laboratory instruction providing experimental training for students in this basic technique complementing theoretical discussion in lecture classes.

圣何塞州立大学将获得一个等温滴定量热仪和差示扫描量热仪与此奖项的主要研究仪器计划。 这些仪器将使圣何塞州立大学、弗朗西斯科州立大学、圣克拉拉大学和索诺马州立大学的研究人员能够研究蛋白质水合的热力学、结合维生素D受体的决定因素、苯乙烯分解代谢途径的机理研究、晚期糖基化终产物的金属结合特性以及细菌素与模型膜相互作用的生物物理特性。 量热计测量化学和生物化学反应过程中或材料分解或发生相变时发生的热变化。 这提供了热力学数据，有助于理解在分子水平上发生了什么。 量热计将被大学生用于他们的研究工作。 它们将被纳入实验室教学，为学生提供这一基本技术的实验培训，补充讲座中的理论讨论。