MRI: Acquisition of an Isothermal Titration Calorimeter and a Differential Scanning Calorimeter

圣何塞州立大学将从主要研究仪器计划获得一台等温滴定量热仪和一台差示扫描量热仪。这些仪器将使圣何塞州立大学、旧金山州立大学、圣克拉拉大学和索诺马州立大学的研究人员能够研究蛋白质水合的热力学、结合维生素D受体的决定因素、苯乙烯分解代谢途径的机制研究、晚期糖基化最终产物的金属结合特性，以及细菌素与模型膜相互作用的生物物理表征。量热计测量在化学反应和生化反应期间或当材料分解或经历相变时发生的热变化。这提供了热力学数据，有助于理解分子水平上正在发生的事情。这些量热计将供本科生在研究工作中使用。它们将被纳入实验室教学，为学生提供这一基本技术的实验培训，补充课堂上的理论讨论。

San Jose State University will acquire an isothermal titration calorimeter and a differential scanning calorimeter with this award from the Major Research Instrumentation program. The instruments will enable researchers at the San Jose State University, San Francisco State University, Santa Clara University and Sonoma State University to investigate the thermodynamics of protein hydration, determinants in binding vitamin D receptor, mechanistic studies of the styrene catabolic pathway, metal binding properties of advanced glycation end products, and biophysical characterization of the interaction of bacteriocins with model membranes. Calorimeters measure the heat changes occurring during chemical and biochemical reactions or when materials decompose or undergo a phase change. This provides thermodynamic data which help to understand what is happening at the molecular level. The calorimeters will be used by undergraduates in their research work. They will be incorporated into laboratory instruction providing experimental training for students in this basic technique complementing theoretical discussion in lecture classes.