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Cellular and Molecular Mechanisms for Defense Against Xenobiotics in Marine Embryos

海洋胚胎中防御异生物质的细胞和分子机制

基本信息

批准号：
9116920
负责人：
David Epel
金额：
$ 4.28万
依托单位：
Stanford University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
1991
资助国家：
美国
起止时间：
1991-08-01 至 1993-01-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9116920&HistoricalAwards=false
关键词：
Cellular Molecular Mechanisms Defense Against

项目摘要

Dr. Epel is seeking support under the Small Grants for Exploratory Research for assistance in moving his lab into a new research direction - the cellular mechanisms by which embryos of aquatic organisms resist deleterious effects of xenobiotics, both natural and anthropogenic. He will focus on embryos since this is a particularly sensitive phase of the organism's life history. This new work combines his long term work and interest in cell and developmental biology with a new interest and concern about the effects of man-introduced chemicals into the marine environment. Besides providing new insights about embryonic defense mechanisms, this work will also yield new and unexpected insights on the normal functioning of cells in both the embryonic and adult phases of the organisms's life history. It will test the possibility that the multi-drug resistance or P-glycoproteins transport system, whose role has been primarily assumed to be of medical importance in terms of transporting hydrophobic drugs out of cells, is normally (i.e., in the historical or evolutionary sense) utilized for removal or detoxification of xenobiotics/pollutants. This idea, if correct, would provide a novel insight into how organisms, and in particular aquatic organisms, can resist the effects of man-made and natural noxious compounds. This work could also provide a "natural history" or evolutionary basis for why these proteins are present and their role in the normal life history of the organism.

埃佩尔博士正在寻求小额赠款的支持，探索性研究，以协助将他的实验室搬到一个新的研究方向-胚胎的细胞机制，水生生物抵抗外来生物的有害影响，自然的和人为的。他将专注于胚胎，因为这是这是生物体生命史中一个特别敏感的阶段。这项新工作结合了他长期的工作和对细胞的兴趣和发育生物学，人类引入海洋的化学物质的影响环境除了提供关于胚胎的新见解防御机制，这项工作也将产生新的和意想不到的对胚胎和胚胎中细胞正常功能的了解以及生物体生命史的成年阶段。它将测试多药耐药或P-糖蛋白运输系统，其作用主要是在将疏水性药物运输到细胞，通常是（即，在历史上或进化上用于去除或解毒异生物质/污染物。这个想法，如果是正确的，将提供一个对生物尤其是水生生物生物体，可以抵御人为和自然有毒物质的影响化合物.这项工作也可以提供一个“自然史”或为什么这些蛋白质存在的进化基础以及它们的在生物体的正常生活史中的作用。