US-Bulgaria Research on Flexoelectricity in Bilayer Lipid Membranes

这个美国-保加利亚博士之间的研究项目。 亚诺什河锡拉丘兹大学的Fendler和Dr. 亚历山大G.液体实验室的彼得罗夫 Georgi的晶体与分子电子学 索菲亚的纳贾科夫大学将研究 双层类脂膜中的挠曲电。 的 保加利亚研究人员发现， 双层类脂膜（BLM）的弯曲结果 在微伏范围的跨膜电位。 的 科学家们有一种理论上的合理化， 现象，并已检查了它的电气 其中包括直接测量 Uf的测定和间接测定 C. 美国人已经使用光学技术 干涉测量法来确定超小， 流体静压引起的BLM运动。 在这份提案中，研究人员建议：（1） 使用实时频闪干涉仪 测量直接确定C中的 周期性弯曲的BLM;（2）确定 同时电和光 BLM的挠曲电系数，以测试 挠曲电理论;（3）研究了挠曲电的基本原理， 各种结构不同的BLM;（4）研究 匡威挠曲电效应（跨膜 电压诱导的膜弯曲）， 干涉全息与光学 干涉测量法;（5）建立对应关系 直接挠曲电效应 （曲率产生的膜极化）和 在同一BLM制剂上的匡威的一个;（6） 研究挠曲电响应的变化 光敏BLM在光照下的光致发光特性， 揭示了一种新的现象，即光致挠曲电性; （7）尝试观察光致挠曲电 现象通过施加重复激光脉冲， 着色的BLM。 生物物理学的这个项目实现了 科学知识的目标， 使美国的顶尖专家和 东欧将联合收割机互补人才 并将资源集中在相互关系密切的领域， 兴趣和能力。

This U.S.-Bulgaria research project between Dr. Janos H. Fendler of Syracuse University and Dr. Alexander G. Petrov of the Laboratory of Liquid Crystals and Molecular Electronics of Georgi Nadjakov University, Sofia, will examine flexoelectricity in bilayer lipid membranes. The Bulgarian researchers have found that periodic bending of a bilayer lipid membrane (BLM) results in microvolt-range transmembrane potential. The Bulgarians have a theoretical rationalization of the phenomenon and have examined it by electrical measurements which included the direct determination of Uf and indirect determination of c. The Americans have used optical interferometry to determine ultrasmall, hydrostatic-pressure-induced movements of BLMs. In this proposal, the researchers propose to: (1) use real-time stroboscopic interferometric measurements to determine directly c in the periodically bent BLMs; (2) determine simultaneously electrical and optical flexoelectric coefficients of BLMs, to test theories of flexoelectricity; (3) investigate a variety of structurally different BLMs; (4) study converse flexoelectric effect (transmembrane voltage-induced membrane curvature) with interferometric holography and optical interferometry; (5) establish a correspondence between the direct flexoelectric effect (curvature-generated membrane polarization) and the converse one on the same BLM preparation; (6) investigate changes of the flexoelectric response of a photosensitive BLM under illumination to reveal a new phenomenon, photoflexoelectricity; and (7) attempt to observe photoflexoelectric phenomena by applying repetitive laser pulses to a pigmented BLM. This project in biophysics fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool resources in areas of strong mutual interest and competence.