U.S.-Netherlands Cooperative Research on the Comparison of Meiotic Chromosome Metabolism in Rats and Yeast

该奖项支持哈佛大学的南希·克莱克纳教授和她的研究生，医学博士露丝·帕德莫尔，与瓦格宁根农业大学遗传学系的克里斯塔·海廷教授和其他人合作进行分子生物学研究，荷兰。这两个实验室都有兴趣了解减数分裂过程中染色体配对和重组的机制及其之间的关系。然而，这两个实验室使用了非常不同的方法和非常不同的生物进行分析，酵母和老鼠。合作的总体科学目标是对这两个生物体中感兴趣的过程进行比较分析。这两个研究小组在酵母分子遗传学和哺乳动物细胞生物学和细胞遗传学方面的互补技能应该会加快两个实验室的进展。减数分裂对于有性繁殖是必不可少的。减数分裂最重要的方面之一是同源染色体之间的配对和重组。这项合作的总体目标是在酵母和高等真核生物中对这些过程进行功能比较。大多数关于减数分裂遗传学的工作是用酵母完成的，而大多数关于减数分裂细胞学的工作是用哺乳动物完成的。将这两条研究路线联系起来是重要的，但也是困难的。

This award supports Professor Nancy Kleckner of Harvard College and her graduate student, Ruth Padmore, M.D., to collaborate in molecular biology research with Professor Christa Heyting and others of the Department of Genetics of the Agricultural University of Wageningen, The Netherlands. Both of these laboratories are interested in understanding the mechanisms of and relationships between chromosome pairing and recombination during meiosis. However the two laboratories have used very different approaches and very different organisms for their analysis, yeast and rats. The overall scientific goal of the collaboration is a comparative analysis of the processes of interest in the two organisms. The complementary skills of the two research groups in yeast molecular genetics and mammalian cell biology and cytogenetics should accelerate progress in both laboratories. Meiosis is essential for sexual reproduction. One of the most important aspects of meiosis is the pairing of and recombination between homologous chromosomes. The general goal of this collaboration is a functional comparison of these processes in yeast and higher eukaryotes. Most work on the genetics of meiosis has been done with yeast, while most work on the cytology of meiosis is done with mammals. It is important but difficult to relate the two lines of research.