U.S.-Netherlands Cooperative Research on the Comparison of Meiotic Chromosome Metabolism in Rats and Yeast

美国-荷兰合作研究大鼠和酵母减数分裂染色体代谢的比较

• 批准号: 9123546
• 负责人: Nancy Kleckner
• 金额: $ 1.5万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-15 至 1995-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9123546&HistoricalAwards=false
• 关键词: U.S.; Netherlands; Cooperative; Research; Comparison

This award supports Professor Nancy Kleckner of Harvard College and her graduate student, Ruth Padmore, M.D., to collaborate in molecular biology research with Professor Christa Heyting and others of the Department of Genetics of the Agricultural University of Wageningen, The Netherlands. Both of these laboratories are interested in understanding the mechanisms of and relationships between chromosome pairing and recombination during meiosis. However the two laboratories have used very different approaches and very different organisms for their analysis, yeast and rats. The overall scientific goal of the collaboration is a comparative analysis of the processes of interest in the two organisms. The complementary skills of the two research groups in yeast molecular genetics and mammalian cell biology and cytogenetics should accelerate progress in both laboratories. Meiosis is essential for sexual reproduction. One of the most important aspects of meiosis is the pairing of and recombination between homologous chromosomes. The general goal of this collaboration is a functional comparison of these processes in yeast and higher eukaryotes. Most work on the genetics of meiosis has been done with yeast, while most work on the cytology of meiosis is done with mammals. It is important but difficult to relate the two lines of research.

该奖项支持教授南希Kleckner的 哈佛学院和她的研究生露丝 Padmore医学博士，在分子水平上 与Christa Heyting教授的生物学研究 和其他遗传学系的 瓦赫宁根农业大学 荷兰. 这两个实验室都是 有兴趣了解 以及染色体配对和 减数分裂期间的重组。 然而，这两个 实验室使用了非常不同的方法 和非常不同的有机体进行分析， 酵母和老鼠。 总体科学目标 该合作是一个比较分析， 这两种生物体中感兴趣的过程。 两种研究方法的互补性 酵母分子遗传学和哺乳动物 细胞生物学和细胞遗传学应该加速 两个实验室的进展。 减数分裂是有性生殖所必需的。 减数分裂最重要的一个方面是 配对和重组 同源染色体 总目标 这种合作是一种功能比较， 酵母和高等真核生物中的这些过程。 大多数关于减数分裂遗传学的工作 用酵母做的，而大多数工作在细胞学上， 减数分裂是由哺乳动物完成的。 是 重要但很难把这两条线联系起来 的研究。