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Investigating the effects of arrhythmia-associated calmodulin mutants on the structure and function of the voltage-gated sodium channel.

Investigating the effects of arrhythmia-associated calmodulin mutants on the structure and function of the voltage-gated sodium channel.
研究心律失常相关钙调蛋白突变体对电压门控钠通道结构和功能的影响。
批准号：
429096
负责人：
Xiao Jenny
金额：
$1.27万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-12-01 至 2020-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=429096&lang=en
关键词：
Calmodulin Cardiac Arrhythmia Late Sodium Current Long-Qt Syndrome Voltage-Gated Sodium Channel X-Ray Crystallography

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"Calcium sensing plays a critical role in regulating physiological processes that are vital to the maintenance of life. A key player in this phenomenon is calmodulin (CaM) which confers hundreds of proteins the ability to detect changes in calcium. One su
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