Expanding access to modified proteins via a novel semi-synthetic platform

通过新型半合成平台扩大修饰蛋白质的获取范围

• 批准号: DP220101037
• 负责人: Prof Richard Payne
• 金额: $ 36.03万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-10-06 至 2025-10-05
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101037
• 关键词: Expanding; access; modified; proteins; via

This project aims to address a critical knowledge gap in understanding how post-translational modifications modulate the structure and activity of proteins. By developing an innovative semi-synthetic platform to produce pure proteins inaccessible by existing methods, the project will reveal how natural protein modifications influence structure and function. Expected outcomes include the delivery of breakthrough technologies for accessing modified proteins for a range of applications in academia and industry, as well as the generation of new knowledge in the fields of chemistry and biology. The project will lead to the training of interdisciplinary early career researchers and has the potential to benefit Australia’s biotechnology sector.

该项目旨在解决理解翻译后修饰如何调节蛋白质结构和活性方面的关键知识差距。通过开发一个创新的半合成平台来生产现有方法无法获得的纯蛋白质，该项目将揭示天然蛋白质修饰如何影响结构和功能。预期成果包括提供突破性技术，用于获取修饰蛋白质，用于学术界和工业界的一系列应用，以及化学和生物学领域新知识的产生。该项目将培训跨学科的早期职业研究人员，并有可能使澳大利亚的生物技术部门受益。