PYI: Computation of Macromolecular Structure
PYI: Computation of Macromolecular Structure
批准号:
9157582
负责人:
Tamar Schlick
金额:
$31.25万
依托单位:
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-10-01 至 2000-08-31
中文摘要
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英文摘要
The proposed research focuses on a multidisciplinary approach toward computation of macromolecular structure. The aim is to (1) develop new algorithms for multivariate minimization and molecular dynamics on supercomputers, and (2) apply them to outstanding problems in nucleic acid and protein dynamics. A key vehicle is the Langevin/Implicit-Euler scheme for molecular dynamics, permitting large time steps and damping high-frequency modes. Efficient conformational searches and global optimization strategies will be applied to important folding problems in DNA and proteins.
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会议论文
MFB: RNA modifications of frameshifting stimulators: cellular platforms to engineer gene expression by computational mutation predictions and functional experiments
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批准号:2330628
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项目类别:Standard Grant
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资助金额:$150.0万
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财政年份:2024
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负责人:Tamar Schlick
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依托单位:
Collaborative Research: Unraveling Structural and Mechanistic Aspects of RNA Viral Frameshifting Elements by Graph Theory and Molecular Modeling
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批准号:2151777
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项目类别:Continuing Grant
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资助金额:$51.0万
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财政年份:2022
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负责人:Tamar Schlick
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依托单位:
RAPID: Exploring Covid-19 RNA Viral Targets By Graph-Theory-Based Modeling
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批准号:2030377
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项目类别:Standard Grant
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资助金额:$20.0万
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财政年份:2020
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负责人:Tamar Schlick
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依托单位:
Workshop Proposal: IMAG Futures Meeting
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批准号:1008193
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项目类别:Standard Grant
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资助金额:$1.0万
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财政年份:2009
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负责人:Tamar Schlick
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依托单位:
Computational Methods for Tertiary RNA Folding and Novel RNA Design
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批准号:0727001
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项目类别:Standard Grant
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资助金额:$40.0万
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财政年份:2007
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负责人:Tamar Schlick
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依托单位:
Simulating Large-Scale Conformational Rearrangements and Reaction Kinetics Profiles in DNA Polymerase Beta to Interpret DNA Synthesis Fidelity Mechanisms
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批准号:0316771
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项目类别:Continuing Grant
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资助金额:$83.88万
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财政年份:2003
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负责人:Tamar Schlick
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依托单位:
Toward RNA Genomics: A Pilot Study in the Analysis, Design, and Prediction of RNA Structures
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批准号:0201160
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项目类别:Continuing Grant
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资助金额:$0.0万
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财政年份:2002
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负责人:Tamar Schlick
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依托单位:
International Workshop: Methods for Macromolecular Modeling
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批准号:0071877
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项目类别:Standard Grant
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资助金额:$2.0万
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财政年份:2000
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负责人:Tamar Schlick
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依托单位:
Postdoc: Brownian Dynamics of DNA Slithering
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批准号:9704681
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项目类别:Standard Grant
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资助金额:$4.62万
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财政年份:1997
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负责人:Tamar Schlick
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依托单位:
New Algorithms for Large Time-Step Molecular Dynamics Simulations and their Application to Protein and Nucleic Acids
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批准号:9310295
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项目类别:Standard Grant
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资助金额:$4.62万
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财政年份:1993
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负责人:Tamar Schlick
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依托单位:
Multivariate Minimization and Molecular Dynamic Techniques for Predicting Nucleic Acid and Protein Structures on Supercomputers
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批准号:9002146
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项目类别:Continuing Grant
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资助金额:$27.5万
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财政年份:1990
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负责人:Tamar Schlick
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依托单位:
Mathematical Sciences Postdoctoral Research Fellowship
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批准号:8705848
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项目类别:Fellowship Award
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资助金额:$7.41万
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财政年份:1987
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负责人:Tamar Schlick
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依托单位:
国内基金
海外基金
基于分位数g-computation的多污染物联合空气质量健康指数构建及预测效果评价
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批准号:--
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项目类别:青年科学基金项目
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资助金额:30万元
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批准年份:2022
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负责人:李嘉琛
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依托单位:
基于g-computation控制纵向数据未测混杂因素的因果推断模型构建及应用研究
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批准号:81903416
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项目类别:青年科学基金项目
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资助金额:19.0万元
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批准年份:2019
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负责人:陈永杰
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依托单位: