Workshop Proposal: IMAG Futures Meeting

现在是评估生物医学、生物学和行为学研究中建模现状的适当时机。2003年，一个小型的跨机构工作组促成了机构间建模和分析小组的成立，并促成了第一个机构间招标公式，即生物医学、生物和行为系统的大规模建模。该征集资助了24个项目，创建了多尺度建模联盟（MSM）。IMAG MSM联盟现在已经是第四个年头了，通过最初的MSM征集所获得的奖项即将到期。从那时起，IMAG的八个政府机构提出了许多其他倡议，这些机构专注于多尺度建模（例如，NIH、NSF、DOE）。由于原有的男男性接触者项目到期，新的男男性接触者项目被介绍给男男性接触者联盟，IMAG决定，今年，代替年度男男性接触者会议，IMAG将举行一次IMAG未来会议，邀请二十位代表不同生物学科的生物学思想家参加（见所附议程）集思广益，探讨生物医学、生物学和行为建模的未来，包括评估目前的进展情况，包括成功和失败。具体而言，会议将为IMAG提供一个机会，评估计算建模在多大程度上成功或失败，在更广泛的研究奋进中发挥作用，并在当前生物医学，生物学和行为建模的挑战和机遇的背景下讨论这些问题。20位受邀的科学家代表生物学的不同领域，以及NIH，NSF和DOE的代表，将讨论计算对生物学和生物医学的影响，以确定失败和成功，并通过会议产生的报告指导未来的工作。

It is now an opportune time to assess the current state of modeling in biomedical, biological and behavioral research. In 2003, a small trans-agency working group resulted in the formation of the Inter-agency Modeling and Analysis Group (IMAG) and the first inter-agency solicitation formultiscale modeling of biomedical, biological and behavioral systems. That solicitation funded 24 projects, creating the Multiscale Modeling Consortium (MSM). The IMAG MSM Consortium is now in its fourth year and the awards made through the original MSM solicitation are expiring. Since then many other initiatives have emerged from the eight IMAG government agencies thathave a focus on multiscale modeling (e.g., NIH, NSF, DOE). As the original MSM projects expire and new MSM projects are introduced to the MSM Consortium, IMAG has determined that this year, in lieu of the annual MSM grantee meeting, IMAG will hold an IMAG Futures Meeting featuring twenty invited broad thinkers in biology representing different biology disciplines(see attached Agenda) to brainstorm ideas concerning the future of biomedical, biological and behavioral modeling, including an assessment of current progress, both successes and failures. Specifically, the meeting will provide an opportunity for IMAG to assess to what extent computational modeling has succeeded or failed to make a difference in the broader research endeavor, and to discuss these issues in the context of current challenges and opportunities for biomedical, biological and behavioral modeling.The twenty invited scientists representing diverse areas of biology, and representatives from NIH, NSF, and DOE, will discuss the impact of computing on biology and biomedicine to identify failures and successes and direct future work through a report generated from the meeting.