A System for Measuring Capillary Blood Flow and Organ Perfusion Using Doppler Ultrasound Aided by Contrast Enhancement

使用多普勒超声辅助对比度增强测量毛细血管血流和器官灌注的系统

• 批准号: 9161006
• 负责人: Beth Schrope
• 金额: $ 4.89万
• 依托单位: RESHET Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-01-15 至 1992-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9161006&HistoricalAwards=false
• 关键词: System; Measuring; Capillary; Blood; Flow

This project will continue research on a new method to analyze blood flow in deep tissues of the body which have slow blood flows and small volumes of movement using doppler ultrasound. In order to optimize the signal-to-noise ratio from these tissues a contrast agent, consisting of galactose microparticles that trap air bubbles, will be employed. Due to the nonlinear properties of this contrast agent, the doppler shifted second harmonic of the transmitted ultrasonic frequency will provide a signal with desirable properties for use in the system. At the second harmonic, the doppler shifted echoes from tissues not containing the contrast agent (surrounding tissues) will be reduced in comparison to tissues containing the agent (capillaries). The concept previously was tested using a mock flow system. It is now proposed to do in-vitro experiments using excised animal organs. The design of hardware which will allow the transmission of one ultrasonic frequency and the detection of the second harmonic of that frequency also is a part of the project. This research is extremely important since no other medical device is available to make such critical measurements. When fully tested and developed, this device should be able to compete in the medical imaging device marketplace.

本项目将继续研究一种新的方法来分析 血液在身体深层组织中流动缓慢 流动和小体积的运动使用多普勒超声。 在 为了优化来自这些组织的信噪比， 造影剂，由半乳糖微粒组成， 将使用气泡。 由于非线性特性 这种造影剂的多普勒频移二次谐波， 发射的超声波频率将提供信号 用于该系统的理想性能。 在第二 谐波，来自组织的多普勒频移回波不包含 造影剂（周围组织）将减少， 与含有试剂的组织（毛细血管）进行比较。 以前的概念是使用模拟流系统进行测试的。 它 现在有人提议用切除的动物做体外实验 机关 硬件的设计将允许传输 一个超声波频率的检测和第二个超声波频率的检测 该频率的谐波也是该项目的一部分。 这项研究是非常重要的，因为没有其他医学 设备可用于进行此类关键测量。 当 经过充分测试和开发，该设备应该能够与 在医疗成像设备市场。