A System for Measuring Capillary Blood Flow and Organ Perfusion Using Doppler Ultrasound Aided by Contrast Enhancement

使用多普勒超声辅助对比度增强测量毛细血管血流和器官灌注的系统

• 批准号: 9301376
• 负责人: Beth Schrope
• 金额: $ 24.98万
• 依托单位: RESHET Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-01-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9301376&HistoricalAwards=false
• 关键词: System; Measuring; Capillary; Blood; Flow

This SBIR Phase II award is for further research on a method to evaluate blood flow in capillary beds using Doppler ultrasound and a contrast media. The Phase I research verified the presence of flows in the capillary beds and that relative changes in flow could be detected. The Phase II research will focus on theoretical and experimental analyses of flow and perfusion and the construction of a laboratory prototype. In addition, a method to determine perfusion without the need for the contrast agent will be explored. The technique to make noninvasive measurements of microcirculatory blood flow should have extensive commercial potential in the medical imaging field for measuring myocardial infarct, vessel occlusion, tissue perfusion, etc. In addition, the device should have applications in the fields of chemical and materials engineering and manufacturing.

该 SBIR 第二阶段奖项旨在进一步研究使用多普勒超声和造影剂评估毛细血管床血流的方法。 第一阶段研究验证了毛细管床中存在流动，并且可以检测到流动的相对变化。 第二阶段研究将侧重于流动和灌注的理论和实验分析以及实验室原型的构建。 此外，还将探索一种无需造影剂即可确定灌注的方法。 这种对微循环血流进行无创测量的技术应该在医学成像领域具有广泛的商业潜力，用于测量心肌梗塞、血管闭塞、组织灌注等。此外，该设备应该在化学和材料工程和制造领域有应用。