Neurochemical predictors of cognition and the impact of brain stimulation

认知的神经化学预测因素和大脑刺激的影响

• 批准号: DP230100092
• 负责人: Prof Paul Dux
• 金额: $ 47.82万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-19 至 2026-01-18
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100092
• 关键词: Neurochemical; predictors; cognition; impact; brain

This project aims to determine how neurochemical equilibrium between excitation and inhibition (E/I balance), across the brain, is associated with executive function and how this balance is influenced by non-invasive brain stimulation. Brain stimulation shows immense promise for enhancing executive function in applied settings, but the neurochemical basis for this is unknown. Using advanced imaging and stimulation techniques, the project aims to provide comprehensive insights into the causal relationship between stimulation, E/I balance and executive function. Outcomes and benefits include identifying neurochemical characteristics that determine stimulation efficacy and informing the design of protocols for applied use.

该项目旨在确定大脑中兴奋和抑制之间的神经化学平衡（E/I平衡）如何与执行功能相关，以及这种平衡如何受到非侵入性脑刺激的影响。脑刺激显示出在应用环境中增强执行功能的巨大前景，但其神经化学基础尚不清楚。该项目利用先进的成像和刺激技术，旨在全面了解刺激，E/I平衡和执行功能之间的因果关系。结果和受益包括识别确定刺激功效的神经化学特征，并为应用程序的设计提供信息。