CA2+-Mediated Signal Transduction in Plants
CA2 - 植物介导的信号转导
基本信息
- 批准号:9205561
- 负责人:
- 金额:$ 15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-08-01 至 1995-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
A new family of Ca2+-dependent protein kinases, called CDPKs, has recently been discovered. CDPKs are unique because they have a novel structure with a kinase domain joined to a Ca2+-binding domain similar to calmodulin. An important long term goal is to understand the function of CDPKs in Ca2+-mediated signal transduction pathways. The model plant system Arabidopsis has been chosen for this purpose. The foundation of the proposal is to determine how Ca2+ regulates CDPK activity. A biochemical and molecular genetic approach will be used to test a model referred to as a "stream-lined version of CaMK II". An E. coli. expression system has been developed to provide functional enzyme for this purpose. Two approaches will be pursued to investigate the biological functions of a specific CDPK isoform: 1) Isoform AK1 and a mutant "unregulated" version of AK1, will be over-expressed in transgenic plants to examine the effects of altering the balance of its activity in vivo. 2) AK1's intracellular location will be determined to provide information on its potential in vivo substrates.
一个新的钙离子依赖性蛋白激酶家族,称为CDPKs, 最近被发现。 CDPK是独一无二的,因为它们有一个 具有连接到Ca2+结合的激酶结构域的新结构 类似于钙调素的结构域。 一个重要的长期目标是 了解CDPKs在Ca2+介导的信号中的功能 转导途径。 模式植物系统拟南芥已经被 为此目的而选择。 该提案的基础是, 确定Ca2+如何调节CDPK活性。 生物化学和 分子遗传学方法将用于测试一个模型, 被称为“CaMK II的流线型版本”。 大肠杆菌表达 已经开发了系统来为此提供功能酶 目的. 将采用两种方法来调查 特异性CDPK同种型的生物学功能:1)同种型AK1 和突变的“不受调控”的AK1,将过度表达, 在转基因植物中, 它在体内的活性。 2)AK1的细胞内定位将是 决心提供关于其体内潜力的信息 印刷受体.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey Harper其他文献
A short critique on biomining technology for critical materials
- DOI:
10.1007/s11274-021-03048-9 - 发表时间:
2021-04-21 - 期刊:
- 影响因子:4.200
- 作者:
Behrooz Abbasi;Jeffrey Harper;Seyedsaeid Ahmadvand - 通讯作者:
Seyedsaeid Ahmadvand
Evidence for an abundant 33,000-dalton polypeptide regulated by cytokinins in cultured tobacco tissues
- DOI:
10.1007/bf00397733 - 发表时间:
1983-08-01 - 期刊:
- 影响因子:3.800
- 作者:
Richard Eichholz;Jeffrey Harper;Georg Felix;Frederick Meins - 通讯作者:
Frederick Meins
Jeffrey Harper的其他文献
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{{ truncateString('Jeffrey Harper', 18)}}的其他基金
The function of lipid flippases in plant growth and thermotolerance
脂质翻转酶在植物生长和耐热性中的功能
- 批准号:
2129234 - 财政年份:2022
- 资助金额:
$ 15万 - 项目类别:
Continuing Grant
Defining the regulatory role of protein O-fucosylation during pollen-pistil communication
定义蛋白质 O-岩藻糖基化在花粉-雌蕊通讯过程中的调节作用
- 批准号:
1947741 - 财政年份:2020
- 资助金额:
$ 15万 - 项目类别:
Standard Grant
NSF-IOS-BSF: Collaborative Research US/Israel: Transcriptome and post-translational regulation of heat stress tolerance in pollen
NSF-IOS-BSF:美国/以色列合作研究:花粉热应激耐受性的转录组和翻译后调控
- 批准号:
1656774 - 财政年份:2017
- 资助金额:
$ 15万 - 项目类别:
Continuing Grant
Calcium Dependent Protein Kinases in Pollen Tube Tip Growth
花粉管尖端生长中的钙依赖性蛋白激酶
- 批准号:
0920624 - 财政年份:2009
- 资助金额:
$ 15万 - 项目类别:
Continuing Grant
Prediction and Validation of Phospho-Regulatory Sites in Crop Plant Proteomes
作物蛋白质组中磷酸调节位点的预测和验证
- 批准号:
0436450 - 财政年份:2004
- 资助金额:
$ 15万 - 项目类别:
Standard Grant
Prediction and Validation of Phospho-Regulatory Sites in Crop Plant Proteomes
作物蛋白质组中磷酸调节位点的预测和验证
- 批准号:
0321450 - 财政年份:2004
- 资助金额:
$ 15万 - 项目类别:
Standard Grant
Signal Transduction by Calcium Dependent Protein Kinases in Higher Plants
高等植物中钙依赖性蛋白激酶的信号转导
- 批准号:
9723539 - 财政年份:1997
- 资助金额:
$ 15万 - 项目类别:
Continuing Grant
NASA/NSF Collaborative Research: Calcium-Mediated Mechano- Sensory Signal Transduction in Plants
NASA/NSF 合作研究:植物中钙介导的机械感觉信号转导
- 批准号:
9416038 - 财政年份:1994
- 资助金额:
$ 15万 - 项目类别:
Continuing Grant
CA2+ - Mediated Signal Transduction in Plants
CA2 - 植物介导的信号转导
- 批准号:
9408101 - 财政年份:1994
- 资助金额:
$ 15万 - 项目类别:
Standard Grant
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