Intramolecular Anodic Olefin Coupling Reactions

本研究的重点是利用阳极偶联的方法， 富电子烯烃提供了一种触发 氧化环化反应。 新的终止组 环化反应将被开发，临时硅 系链将用于控制相对和绝对 季碳合成立体化学，顺序 化学反应-电化学环化策略将 可用于构建复杂的环体系， 将探索串联环化反应的起始。 %%% 有了这个更新奖，合成有机计划是 支持Kevin D博士的研究。莫勒 华盛顿大学化学系。 穆勒医生 他的工作重点是展示有机食品的多功能性， 电化学作为有机合成的工具。

The focus of this research is the use of aniodic coupling of electron rich alkenes to provide a method for triggering oxidative cyclization reactions. New terminating groups for cyclization reactions will be developed, temporary silicon tethers will be employed to control the relative and absolute stereochemistry of quaternary carbon synthesis, sequential chemical reaction-electrochemical cyclization strategies will be used to construct complex ring systems and the aniodic initiation of tandem cyclization reactions will be explored. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Kevin D. Moeller of the Department of Chemistry at Washington University. Dr. Moeller will focus his work on demonstrating the versatility of organic electrochemistry as a tool for organic synthesis.