Intramolecular Anodic Olefin Coupling Reactions

本研究的重点是利用富电子烯烃的无氧偶联为引发氧化环化反应提供一种方法。新的环化反应终止基团将被开发，临时硅系链将被用来控制季碳合成的相对和绝对立体化学。顺序化学反应-电化学环化策略将用于构建复杂的环体系，并将探索串联环化反应的无氧引发。有了这个更新奖，合成有机项目支持了华盛顿大学化学系凯文·d·莫勒博士的研究。Moeller博士将专注于展示有机电化学作为有机合成工具的多功能性。

The focus of this research is the use of aniodic coupling of electron rich alkenes to provide a method for triggering oxidative cyclization reactions. New terminating groups for cyclization reactions will be developed, temporary silicon tethers will be employed to control the relative and absolute stereochemistry of quaternary carbon synthesis, sequential chemical reaction-electrochemical cyclization strategies will be used to construct complex ring systems and the aniodic initiation of tandem cyclization reactions will be explored. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Kevin D. Moeller of the Department of Chemistry at Washington University. Dr. Moeller will focus his work on demonstrating the versatility of organic electrochemistry as a tool for organic synthesis.