Intramolecular Anodic Olefin Coupling Reactions

该项目将继续开发新的氧化环化反应。氧化环化反应是构建有机分子的有力工具，因为它们都能在不放弃引发反应的官能团的情况下生成新的环系，并逆转富电子官能团的极性，使它们可以以全新的方式使用。这些功能的结合创造了独特的机会，可以开发新的合成途径来生产高度功能化的产品。为此，将进行一项深入的研究，考察反应的范围和活性自由基阳离子中间体的性质，这是它们成功的关键。有了这个奖项，有机和高分子化学计划支持圣路易斯华盛顿大学化学系的凯文·D·莫勒教授的研究。默勒教授的研究利用电化学来探索新的氧化环化反应。使用电化学来实现反应，避免了对化学氧化剂的需要，从而避免了处理不可避免地由这种试剂产生的废物的需要。这将反应对环境的影响降至最低。通过这种方式，正在研究的化学不仅展示了正在开发的合成方法的力量，而且突出了电化学在未来开发可持续化学过程的潜力。

This project will continue work on the development of new oxidative cyclization reactions. Oxidative cyclization reactions are powerful tools for constructing organic molecules because they both generate new ring systems without giving up the functionality used to initiate the reaction, and reverse the polarity of electron-rich functional groups so that they can be used in entirely new ways. The combination of these features creates unique opportunities to develop novel synthetic pathways to highly functionalized products. For this reason, an intensive study will be conducted examining both the scope of the reactions and the nature of the reactive radical cation intermediates that are central to their success.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kevin D. Moeller of the Department of Chemistry at Washington University in St. Louis. Professor Moeller's research capitalizes on the use of electrochemistry to explore new oxidative cyclization reactions. The use of electrochemistry to effect the reactions avoids the need for a chemical oxidant, and hence, the need for disposing the waste that inevitably results from such a reagent. This minimizes the environmental impact of the reactions. In this way, the chemistry being studied not only illustrates the power of the synthetic methods being developed, but also highlights the potential of electrochemistry for developing sustainable chemical processes in the future.