Intramolecular Anodic Olefin Coupling Reactions

分子内阳极烯烃偶联反应

• 批准号: 0809142
• 负责人: Kevin Moeller
• 金额: $ 39.9万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0809142&HistoricalAwards=false
• 关键词: Intramolecular; Anodic; Olefin; Coupling; Reactions

This project will continue work on the development of new oxidative cyclization reactions. Oxidative cyclization reactions are powerful tools for constructing organic molecules because they both generate new ring systems without giving up the functionality used to initiate the reaction, and reverse the polarity of electron-rich functional groups so that they can be used in entirely new ways. The combination of these features creates unique opportunities to develop novel synthetic pathways to highly functionalized products. For this reason, an intensive study will be conducted examining both the scope of the reactions and the nature of the reactive radical cation intermediates that are central to their success.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kevin D. Moeller of the Department of Chemistry at Washington University in St. Louis. Professor Moeller's research capitalizes on the use of electrochemistry to explore new oxidative cyclization reactions. The use of electrochemistry to effect the reactions avoids the need for a chemical oxidant, and hence, the need for disposing the waste that inevitably results from such a reagent. This minimizes the environmental impact of the reactions. In this way, the chemistry being studied not only illustrates the power of the synthetic methods being developed, but also highlights the potential of electrochemistry for developing sustainable chemical processes in the future.

该项目将继续致力于开发新的氧化环化反应。氧化环化反应是构建有机分子的有力工具，因为它们既产生新的环系统，又不放弃用于引发反应的官能团，并逆转富电子官能团的极性，使它们可以以全新的方式使用。这些特征的组合为开发高度功能化产品的新型合成途径创造了独特的机会。 因此，将进行深入的研究，检查反应的范围和活性自由基阳离子中间体的性质，这是他们成功的核心。有了这个奖项，有机和大分子化学计划支持凯文·D教授的研究。位于圣路易斯的华盛顿大学化学系的Moeller说。 Moeller教授的研究利用电化学来探索新的氧化环化反应。使用电化学来实现反应避免了对化学氧化剂的需要，并且因此避免了对处理不可避免地由这样的试剂产生的废物的需要。这最大限度地减少了反应对环境的影响。通过这种方式，正在研究的化学不仅说明了正在开发的合成方法的力量，而且还突出了电化学在未来开发可持续化学过程的潜力。