Intramolecular Anodic Olefin Coupling Reactions

该项目将继续致力于开发新的氧化环化反应。氧化环化反应是构建有机分子的有力工具，因为它们既能生成新的环系统，又不会放弃引发反应的功能，还能逆转富含电子的官能团的极性，从而可以以全新的方式使用它们。这些特点的结合创造了独特的机会，以开发新的合成途径，以高度功能化的产品。由于这个原因，将进行深入的研究，检查反应的范围和反应性自由基阳离子中间体的性质，这是其成功的核心。通过这个奖项，有机和大分子化学项目支持了圣路易斯华盛顿大学化学系凯文·d·莫勒教授的研究。莫勒教授的研究利用电化学来探索新的氧化环化反应。使用电化学来影响反应，避免了对化学氧化剂的需要，因此，也就不需要处理这种试剂不可避免地产生的废物。这样可以最大限度地减少反应对环境的影响。通过这种方式，正在研究的化学不仅说明了正在开发的合成方法的力量，而且还强调了电化学在未来开发可持续化学过程的潜力。

This project will continue work on the development of new oxidative cyclization reactions. Oxidative cyclization reactions are powerful tools for constructing organic molecules because they both generate new ring systems without giving up the functionality used to initiate the reaction, and reverse the polarity of electron-rich functional groups so that they can be used in entirely new ways. The combination of these features creates unique opportunities to develop novel synthetic pathways to highly functionalized products. For this reason, an intensive study will be conducted examining both the scope of the reactions and the nature of the reactive radical cation intermediates that are central to their success.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kevin D. Moeller of the Department of Chemistry at Washington University in St. Louis. Professor Moeller's research capitalizes on the use of electrochemistry to explore new oxidative cyclization reactions. The use of electrochemistry to effect the reactions avoids the need for a chemical oxidant, and hence, the need for disposing the waste that inevitably results from such a reagent. This minimizes the environmental impact of the reactions. In this way, the chemistry being studied not only illustrates the power of the synthetic methods being developed, but also highlights the potential of electrochemistry for developing sustainable chemical processes in the future.