New Synthetic Methods for Building Chip-Based Libraries

构建基于芯片的文库的新合成方法

• 批准号: 0613077
• 负责人: Kevin Moeller
• 金额: $ 42万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0613077&HistoricalAwards=false
• 关键词: New; Synthetic; Methods; Building; Chip

This project is focused on the development of chemistry needed for the site-selective preparation of molecules next to the electrodes in chip-based, addressable microarrays. Further studies of the reagent synthesis/confinement strategies developed in the previous funding period, site-selective use of Lewis acids in microarrays, and strategies to construct core molecular scaffolds will be performed. In addition to these synthetic efforts, new polymers and linkers for attaching small molecules to the surface of a microarray, utility of the microarray for determining relative binding constants for the molecules in a library with an added biomolecule will also be investigated. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kevin D. Moeller of the Department of Chemistry at Washington University. Professor Moeller s research efforts revolve around the efficient preparation of molecular libraries (collection of target compounds) in chip-based, addressable microarrays. Libraries in such format have significant applications in biomedical research, as they could be used to identify target gene products with the tiny amounts of material generated by biological systems. Ability to prepare libraries in such microarray format is also important for developing materials with novel properties.

该项目的重点是开发基于芯片的可寻址微阵列中电极旁边分子的位点选择性制备所需的化学物质。 进一步研究的试剂合成/限制策略开发的前一个资助期，在微阵列中的刘易斯酸的位点选择性使用，和战略，以构建核心分子支架将进行。 除了这些合成的努力，新的聚合物和连接器连接到微阵列的表面的小分子，微阵列的效用，用于确定相对结合常数的分子库中添加的生物分子也将被调查。 有了这个奖项，有机和高分子化学计划是支持教授凯文D。华盛顿大学化学系的Moeller说。 Moeller教授的研究工作围绕着在基于芯片的可寻址微阵列中有效制备分子库（目标化合物的收集）。 这种形式的文库在生物医学研究中具有重要的应用，因为它们可以用于鉴定生物系统产生的微量物质的靶基因产物。 以这种微阵列形式制备文库的能力对于开发具有新特性的材料也很重要。