New Synthetic Methods for Building Chip-Based Libraries

该项目的重点是开发基于芯片的可寻址微阵列中电极旁分子的选择性制备所需的化学物质。将进一步研究试剂合成/约束策略，微阵列中Lewis酸的位点选择性使用，以及构建核心分子支架的策略。除了这些合成的努力之外，用于将小分子附着在微阵列表面的新型聚合物和连接剂，以及微阵列用于确定带有添加生物分子的文库中分子的相对结合常数的效用也将被研究。有了这个奖项，有机和大分子化学项目支持华盛顿大学化学系凯文·d·莫勒教授的研究。Moeller教授的研究工作围绕着在基于芯片的可寻址微阵列中有效制备分子文库（目标化合物的收集）。这种格式的文库在生物医学研究中有重要的应用，因为它们可以用生物系统产生的微量物质来识别目标基因产物。以这种微阵列格式制备文库的能力对于开发具有新特性的材料也很重要。

This project is focused on the development of chemistry needed for the site-selective preparation of molecules next to the electrodes in chip-based, addressable microarrays. Further studies of the reagent synthesis/confinement strategies developed in the previous funding period, site-selective use of Lewis acids in microarrays, and strategies to construct core molecular scaffolds will be performed. In addition to these synthetic efforts, new polymers and linkers for attaching small molecules to the surface of a microarray, utility of the microarray for determining relative binding constants for the molecules in a library with an added biomolecule will also be investigated. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kevin D. Moeller of the Department of Chemistry at Washington University. Professor Moeller s research efforts revolve around the efficient preparation of molecular libraries (collection of target compounds) in chip-based, addressable microarrays. Libraries in such format have significant applications in biomedical research, as they could be used to identify target gene products with the tiny amounts of material generated by biological systems. Ability to prepare libraries in such microarray format is also important for developing materials with novel properties.