New Synthetic Methods for Building Chip-Based Libraries

构建基于芯片的文库的新合成方法

• 批准号: 0314057
• 负责人: Kevin Moeller
• 金额: $ 39万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0314057&HistoricalAwards=false
• 关键词: New; Synthetic; Methods; Building; Chip

The focus of this research is to establish the range of reactions that can be accomplished on a chip-based platform. First, a protocol for moving known mediated electrochemical reactions to the chips will be developed. Second, electrochemically cleavable linkers will be developed for connecting molecules to the chips so that individual molecules in the library can be isolated. Third, strategies for spatially confining transition metal catalyzed reactions to specific locations on the chips will be developed.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Kevin D. Moeller in the Department of Chemistry at Washington University. Professor Moeller will focus his research efforts using electrochemistry to build molecular libraries on chips. The research has broader impact for the pharmaceutical industry and for the agricultural industry. Further, the project will provide an excellent venue for the training of undergraduate and graduate students.

这项研究的重点是建立可以在基于芯片的平台上完成的反应范围。 首先，将开发用于将已知介导的电化学反应移动到芯片的方案。 第二，将开发电化学可切割的接头，用于将分子连接到芯片，以便可以分离文库中的单个分子。第三，将开发在空间上将过渡金属催化反应限制在芯片上特定位置的策略。默勒在华盛顿大学化学系。Moeller教授的研究重点是利用电化学在芯片上构建分子库。 这项研究对制药业和农业产生了更广泛的影响。 此外，该项目将为本科生和研究生的培训提供一个极好的场所。