Enantioselective Reactions of Coordinated Ligands

配位配体的对映选择性反应

• 批准号: 9208207
• 负责人: Joseph Templeton
• 金额: $ 54.8万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-15 至 1997-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9208207&HistoricalAwards=false
• 关键词: Enantioselective; Reactions; Coordinated; Ligands

This award in the Inorganic, Bioinorganic, and Organometallic Program provides continued support for research by Dr. Joseph L. Templeton of the Chemistry Department, University of North Carolina, on the reactions of coordinated 4-electron donor ligands. Templeton will synthesize chiral metal alkyne complexes of niobium (III) and tungsten (II) containing new alkyne, alcohol and eneyne ligands. Enantioselective reactions with resolved metal complexes will be used to build intermediate size rings, to promote 1,4-conjugate addition across the olefin tail of coordinated eneynes, and to cleave the alkyne to generate organic products. Diastereoselective nucleophilic additions will be promoted by aldehyde and ketone complexes. Platinum (IV) alkyne complexes will be studied, and nitrogen activation will also be explored using analogous reactions with isoelectronic dinitrogen. %%% Organic molecules will be tranformed while they are attached to a metal. The reactions are of a special type in which the "handedness" or chirality of the product is controlled. Development of powerful and versatile reagents which can be selective in this way is the important goal of this research. The results have implications for many industrial processes which are catalyzed by transition metals and for the synthesis of pure organic compounds for use in drug manufacture.

该奖项在无机，生物无机和有机化学 项目为约瑟夫博士的研究提供持续支持 L.北方大学化学系的邓普顿 卡罗莱纳，关于配位4-电子供体的反应 配体。 Templeton将合成手性金属炔 含新的铌（III）和钨（II）的络合物 炔、醇和烯炔配体。 对映选择性反应 与解决的金属络合物将被用来建立 中等大小的环，以促进1，4-共轭加成 穿过配位烯炔的烯烃尾部， 生成有机产物。 映选择 醛和酮将促进亲核加成 配合物 将研究铂（IV）炔络合物， 和氮活化也将探索使用类似的 与等电子二氮反应。 %%% 当有机分子附着在 一种金属 反应是一种特殊的类型，其中 控制产物的“手性”或手性。 开发功能强大、用途广泛的试剂， 选择性是本研究的重要目标。 这些结果对许多工业过程都有意义 其由过渡金属催化并且用于合成 用于制药的纯有机化合物。