Bond Activation and Bond Formation Reactions with Platinum Reagents

这项研究项目由化学部化学合成计划资助，将开发基于铂(II)和铂(IV)有机金属络合物的简单相互转化来激活C-H键和形成C-C键的方法。北卡罗来纳大学教堂山分校的约瑟夫·L·邓普顿教授将开发一种方法，从烷烃和芳烃试剂中丰富的和顽固的C-H键形成C-C键。通过控制反应性五配位铂中间体的进入，将促进C-H键的活化和C-C键的形成。将进行实验以阐明有机金属铂反应循环的机理。虽然在C-H活化和C-C键形成反应方面都取得了重大进展，但大部分的焦点都集中在有机键的细节上，因为它们重新洗牌伙伴。这个项目将着眼于辅助配体在整个反应周期中保持完整的金属上的关键作用。这项工作可能导致通过插入反应和耦合机制形成更有效的碳-碳键的方法。过渡金属促进的化学转化对环境是有益的，因为就试剂和产物的原子一致性而言，这些反应是经济的。这一方法将对制药、化工和农业行业中依赖高效制备化学品的领域产生影响。更广泛的影响包括通过独立的实验研究项目扩大本科生和研究生的教育。此外，邓普顿教授将参与咨询活动，这些活动不仅在教堂山校园，而且在整个北卡罗来纳州推广科学。

This research project, funded by the Chemical Synthesis Program of the Chemistry Division, will develop methods for activating C-H bonds and for forming C-C bonds based on facile interconversions of platinum(II) and platinum(IV) organometallic complexes. Professor Joseph L. Templeton of the University of North Carolina at Chapel Hill will develop methods for forming C-C bonds from abundant and recalcitrant C-H bonds in alkane and arene reagents. Activation of C-H bonds and formation of C-C bonds will be promoted by controlling access to reactive five-coordinate platinum intermediates. Experiments to elucidate the mechanism of organometallic platinum reaction cycles will be undertaken. Although significant progress has been made in both C-H activation and C-C bond formation reactions, most of the focus has been on the details of the organic bonds as they reshuffle partners. This project will look at the critical role of ancillary ligands on the metal that remain intact throughout the reaction cycle.This work could lead to more efficient methods of carbon-carbon bond formation through both insertion reactions and coupling mechanisms. Chemical transformations promoted with transition metals are environmentally beneficial since the reactions are economical with respect to atomic identity of reagents and products. This methodology will have an impact on areas that rely on the efficient preparation of chemicals within the pharmaceutical, chemical, and agricultural industries. Broader impacts include expanding the education of both undergraduate and graduate students through independent experimental research projects. In addition, Professor Templeton will participate in advisory activities that promote science not only on the Chapel Hill campus but across the state of North Carolina.