Population Genetics of DNA Polymorphisms

DNA 多态性的群体遗传学

• 批准号: 9209262
• 负责人: Lynn Jorde
• 金额: $ 18.1万
• 依托单位: University of Utah College of Medicine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-01 至 1997-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9209262&HistoricalAwards=false
• 关键词: Population; Genetics; DNA; Polymorphisms

Geneological records are an important resource for the study of human genetic change over short periods of time. The primary objective of this research is to utilize the archival records of the Aland Islands, Finland, for such two such analyses. First, excellent archival records are available for the past 250 years, facilitating long-term demographic studies as well as the construction of multigenerational pedigrees. Second, this population has high frequencies of several genetic diseases that are very rare in other populations. The investigators are interested in determining the evolutionary forces responsible for these disease frequencies. The initial goal of this project is to complete the computer entry of archival records from Aland so that they can be used in a computerized construction of pedigrees for the entire population. This will allow the analysis of inbreeding levels, nonrandom mating, the degree of genetic isolation, and the extent to which individual ancestral founders may have made disproportionate genetic contributions to the current generation. These studies will have evolutionary significance, and they will help to explain why the Aland Islands population has a high incidence of some genetic diseases.

遗传学记录是研究 人类基因在短时间内的变化。 主 这项研究的目的是利用档案记录， 芬兰奥兰群岛进行了这两项分析。 第一、 在过去的250年里， 促进长期的人口研究以及 构建多代系谱。 二是这个 人群中有几种遗传疾病的高频率， 在其他人群中非常罕见。 调查人员正在 有兴趣确定进化的力量 这些疾病的频率。 这个项目的最初目标是完成计算机 从奥兰的档案记录，以便他们可以在一个 计算机化构建整个人群的谱系。 这将允许分析近亲繁殖水平，非随机 交配，遗传隔离的程度，以及 个别祖先的创始人可能已经做出了不成比例的 基因对当代人的影响这些研究将 具有进化的意义，它们将有助于解释为什么 奥兰群岛人口中某些遗传病发病率很高， 疾病