A Genetic Study of Inbreeding in Finland

芬兰近亲繁殖的遗传学研究

• 批准号: 8703841
• 负责人: Lynn Jorde
• 金额: $ 8.17万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-15 至 1990-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8703841&HistoricalAwards=false
• 关键词: Genetic; Study; Inbreeding; Finland

This grant allows Dr. Jorde and his collaborators to continue their analysis of Finnish population records which cover the period from the seventeenth through the twentieth centuries. These data are valuable not only for what they show about population distribution and the social class of individuals but because of the information they provide about marriage partners. It is possible for example to determine the distance between mates' birthplace. This allows population movement over time to be determined. What is even more interesting is the fact that marriages between close relatives can also be tracked. For example when first cousins wished to marry, a royal dispensation was required and these were recorded and saved. The project has three goals: 1: to determine spatial and temporal variation in inbreeding rates based on royal dispensation records; 2: to search for the causal variables which determine the spatial and temporal variation in inbreeding rates. A number of specific hypotheses will be tested; 3: to compare inbreeding patterns with spatial variation in the frequencies of autosomal recessive diseases. This research is important because it will shed additional light on the determinants of human breeding patterns. It will also help to explicate the relationship between inbreeding and recessive diseases. Finland has very high frequencies of at least 26 recessive diseases which are extremely rare elsewhere. By examining inbreeding in Finland one can help determine whether this disease distribution is due to founder effect, genetic drift or to inbreeding.

这笔赠款使乔德博士和他的合作者能够继续 他们对芬兰人口记录的分析， 从十七世纪到二十世纪。 这些数据的价值不仅在于它们所显示的 人口分布和个人的社会阶级， 因为他们提供了关于婚姻伴侣的信息。 例如，可以确定 朋友的出生地这使得人口流动随着时间的推移， 被确定。更有趣的是， 近亲之间的婚姻也可以跟踪。为 例如，当第一代表兄弟姐妹希望结婚时，皇家特许 这些都被记录下来并保存下来。 该项目有三个目标：1：确定空间和时间 基于皇家分配的近亲繁殖率的变化 记录; 2：寻找决定 近亲繁殖率的时空变化。一些 具体的假设将进行测试; 3：比较近亲繁殖 常染色体频率的空间变异模式 隐性疾病 这项研究很重要，因为它将进一步阐明 人类繁殖模式的决定因素它还将帮助 阐明了近交与隐性的关系 疾病芬兰有非常高的频率，至少26 在其他地方极为罕见的隐性疾病。通过 研究芬兰的近亲繁殖可以帮助确定 这种疾病的分布是由于奠基者效应，遗传漂变 或近亲繁殖。