Effects of Mineral-Organic Bonding Forces on the Mechanical Properties of Bone Tissue

矿物-有机结合力对骨组织力学性能的影响

• 批准号: 9210253
• 负责人: Nejat Guzelsu
• 金额: $ 22.6万
• 依托单位: Rutgers, The State University of New Jersey-RBHS-Robert Wood
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1996-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9210253&HistoricalAwards=false
• 关键词: Effects; Mineral; Organic; Bonding; Forces

This project will determine if bonding characteristics between bone minerals and organic phases play a role in the mechanical properties of aged or osteoporotic bones, in addition to changes in bone mass. The bonding between the bone mineral and the organic constituents will be altered by treating the bone tissue with special buffer solutions which contain potential determining and specifically adsorbed ions of bone mineral. The mechanical properties including the elastic moduli, yield and ultimate stress will be examined. This project is important since it is thought that osteoporosis not only involves changes in bone mass but also changes in bone quality. The quality of the bone is a function of the mineral-organic bonding characteristics that these investigators will study.

该项目将确定如果 之间的粘结特性 骨矿物质和有机相 在机械中发挥作用 老化或老化性能 除了骨骼的变化， 骨量 之间的结合 骨矿物质和有机质 成分将被改变， 治疗骨组织， 特殊缓冲溶液， 包含潜在的决定性因素， 骨特异性吸附离子 矿物。力学性能 包括弹性模量、屈服 极限应力是 考察 这个项目很重要，因为它 认为骨质疏松症不 只涉及骨质的变化 也会改变骨质。 骨头的质量 矿物有机质功能 这些键合特性 研究人员将研究。