The Chemistry of Fungal Antagonism and Defense

真菌拮抗和防御的化学

• 批准号: 0079141
• 负责人: James Gloer
• 金额: $ 29.25万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0079141&HistoricalAwards=false
• 关键词: Chemistry; Fungal; Antagonism; Defense

The focus of this research is the study of mycoparasitic/fungicolous fungi that colonize the stromata and polypores of other fungi. Colonists obtained from the southern, subtropical latitudes of southern Georgia and northern Florida will increase the biodiversity found in samples already collected from Illinois. Activity of isolates from the colonists against Aspergillus flavus, Fusarium verticillioides and the agriculturally important insect Spodoptera frugiperda will be tested. The results of the project will help to determine whether an ecological rationale can be useful as a guide to the discovery of new and potentially bioactive natural products.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. James B. Gloer of the Department of Chemistry at the University of Iowa. Dr. Gloer, in collaboration with Drs. Donald T. Wicklow and Patrick F. Dowd of the U.S. Department of Agriculture, will focus his work on investigating the the fungal invasion of long-lived or "persistent" stromata of other fungi. Since the invasion may involve antibiosis, the fungal colonists are a potential source of anti fungal agents. The work is an excellent training ground for graduate students and the work could have impact on the pharmaceutical and agricultural industries.

本研究的重点是研究寄生在其他真菌的基质和多孔菌中的真菌寄生/真菌寄生真菌。 从南部、亚热带纬度的格鲁吉亚南部和北方佛罗里达获得的殖民者将增加已经从伊利诺斯州收集的样本中发现的生物多样性。 将测试来自殖民者的分离物对黄曲霉、轮枝镰刀菌和农业上重要的昆虫草地贪夜蛾的活性。 该项目的结果将有助于确定生态学原理是否可以作为发现新的和潜在的生物活性天然产品的指南。有了这个更新奖，有机和大分子化学计划支持博士的研究。爱荷华州大学化学系的Gloer说。 Gloer博士与Donald T.威克洛和帕特里克F.美国农业部的Dowd将把他的工作重点放在调查真菌入侵其他真菌的长寿命或“持久性”基质上。 由于入侵可能涉及寄生，真菌定居者是抗真菌剂的潜在来源。 这项工作是研究生的一个很好的培训基地，这项工作可能会对制药和农业行业产生影响。