The Chemistry of Fungal Antagonism and Defense

这项研究的重点是研究真菌寄生/真菌真菌，这些真菌定植于其他真菌的基质和多孔中。从佐治亚州南部亚热带纬度和佛罗里达州北部获得的殖民者将增加从伊利诺伊州采集的样本中发现的生物多样性。来自殖民地的分离株对黄曲霉、黄萎病镰刀菌和农业上重要的昆虫果蝇的活性将进行测试。该项目的结果将有助于确定生态学原理是否可以作为发现新的和潜在的生物活性天然产品的指南。有了这个续展奖，有机和高分子化学计划支持爱荷华大学化学系的詹姆斯·B·格洛尔博士的研究。Gloer博士将与美国农业部的Donald T.Wicklow博士和Patrick F.Dowd博士合作，重点研究真菌对其他真菌的长期或“持久”基质的侵袭。由于入侵可能涉及抗生素，真菌定植者是抗真菌药物的潜在来源。这项工作对研究生来说是一个很好的培训基地，这项工作可能会对制药和农业行业产生影响。

The focus of this research is the study of mycoparasitic/fungicolous fungi that colonize the stromata and polypores of other fungi. Colonists obtained from the southern, subtropical latitudes of southern Georgia and northern Florida will increase the biodiversity found in samples already collected from Illinois. Activity of isolates from the colonists against Aspergillus flavus, Fusarium verticillioides and the agriculturally important insect Spodoptera frugiperda will be tested. The results of the project will help to determine whether an ecological rationale can be useful as a guide to the discovery of new and potentially bioactive natural products.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. James B. Gloer of the Department of Chemistry at the University of Iowa. Dr. Gloer, in collaboration with Drs. Donald T. Wicklow and Patrick F. Dowd of the U.S. Department of Agriculture, will focus his work on investigating the the fungal invasion of long-lived or "persistent" stromata of other fungi. Since the invasion may involve antibiosis, the fungal colonists are a potential source of anti fungal agents. The work is an excellent training ground for graduate students and the work could have impact on the pharmaceutical and agricultural industries.