U.S.-France Cooperative Research: Population Dynamics and Evolution of Drosophila Transposable Elements

美法合作研究：果蝇种群动态和转座元件的进化

• 批准号: 9216305
• 负责人: Daniel Hartl
• 金额: $ 1.53万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9216305&HistoricalAwards=false
• 关键词: U.S.; France; Cooperative; Research; Population

This three-year award supports U.S.-France cooperative research in population and evolutionary genetics between Daniel L. Hartl, Harvard University, and Jean R. David, Biology and Evolutionary Genetics Laboratory, the French National Center for Scientific Research in Gif-sur-Yvette, France. The research focuses on the evolutionary genetics of the transposable element mariner among species of Drosophila. The investigators will study the rates and patterns of sequence evolution to determine the mode of inheritance of these elements in different lineages of Drosophila. The transposable element in mariner makes it a very strong candidate for genetic engineering by means of germline transformation. The element is short and has a simple sequence organization. Mariner sequences are found in a wide range of genomes. The U.S. investigator brings to this collaboration expertise in cloning, sequencing and analysis of the mariner elements. The French group has an internationally recognized collection of Drosophila species. They will carry out the Drosophila screening of mariner elements and some of the cloning and sequencing. The project will provide data on the evolutionary biology of the transposable mariner element and may assist in the development of new tools for genetic manipulation of diverse organisms.

这个为期三年的奖项支持哈佛大学的丹尼尔·哈特尔（Daniel L. Hartl）和法国国家科学研究中心生物学和进化遗传学实验室的让·r·大卫（Jean R. David）在人口和进化遗传学方面的合作研究。对果蝇转座因子mariner的进化遗传学进行了研究。研究人员将研究序列进化的速率和模式，以确定这些元素在果蝇不同谱系中的遗传模式。mariner的转座因子使其成为通过种系转化进行基因工程的一个强有力的候选者。元素很短，具有简单的序列组织。水手序列存在于广泛的基因组中。美国研究人员为这次合作带来了克隆、测序和分析海洋元素的专业知识。这家法国集团拥有国际公认的果蝇物种收藏。他们将对果蝇进行水手基因的筛选以及部分克隆和测序。该项目将提供转座水手基因的进化生物学数据，并可能有助于开发对不同生物体进行遗传操作的新工具。