Vortex Filaments in 3 Dimensional Excitable Media

3 维可激励介质中的涡旋细丝

• 批准号: 9216567
• 负责人: Arthur Winfree
• 金额: $ 55.7万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9216567&HistoricalAwards=false
• 关键词: Vortex; Filaments; Dimensional; Excitable; Media

The principal investigator will study three dimensional excitable media, both in terms of chemical reactions but also are related to the electrophysiology of the heart. The key ideas of the project are 1) the normal heart muscle is an excitable medium; 2) some aspects of the dynamics of excitable media are generic, notably their vortex excitations; 3) these aspects are inherently 3-dimensional; 4) in heart muscle these vortex excitations are responsible for the most pernicious arrhythmias, but are almost impossible to study 3-dimensionally in living heart muscle; 5) they can be studied computationally and in chemically excitable media, both of which support action-potential-like propagation in three dimensions; 6) the utility of this comparison has been validated in two dimensional studies; 7) the pure computation for equations of mechanism should be complemented by experiments; 8) such experiments can be implemented by adapting existing computational procedures in optical tomography to existing computational procedures for analysis and display of the data that are currently obtained by supercomputer solution of the mechanistic equations of cardiac electrophysiology and of the analogous chemical kinetics. The investigator will solve the "three- dimensional" for the mechanisms and use computer-assisted optical tomography to observe three dimensional activation wavefronts in the chemical medium during the analog to these arrhythmias. The current project is being supported by four programs at the National Science Foundation: Theoretical and Computational Chemistry, Applied & Computational Mathematics, Physiology, and Computational Biology Activities.

首席研究员将研究三维可兴奋介质，不仅涉及化学反应，还涉及心脏的电生理学。 该项目的核心思想是：1）正常心肌是一种可兴奋介质； 2）可激发介质动力学的某些方面是通用的，特别是它们的涡旋激发； 3）这些方面本质上是3维的； 4) 在心肌中，这些涡流激励是最有害的心律失常的原因，但几乎不可能在活体心肌中进行 3 维研究； 5）它们可以通过计算和化学激发介质进行研究，这两种介质都支持在三个维度上类似动作电位的传播； 6) 这种比较的实用性已在二维研究中得到验证； 7) 机理方程的纯计算应辅以实验； 8)这样的实验可以通过将光学断层扫描中现有的计算程序调整为用于分析和显示当前通过心脏电生理学和类似的化学动力学的机械方程的超级计算机解而获得的数据的现有计算程序来实现。 研究人员将解决机制的“三维”问题，并在模拟这些心律失常的过程中使用计算机辅助光学断层扫描来观察化学介质中的三维激活波前。 当前的项目得到了国家科学基金会四个项目的支持：理论和计算化学、应用和计算数学、生理学和计算生物学活动。