Functions of Hormones and Circadian Rhythms in the Regulation of Behavior

激素和昼夜节律在行为调节中的作用

• 批准号: 9219742
• 负责人: James Truman
• 金额: $ 22.74万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-15 至 1995-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9219742&HistoricalAwards=false
• 关键词: Functions; Hormones; Circadian; Rhythms; Regulation

To be adaptive, an animal's behavior must change depending on the organism's physiological or developmental state. Dr. Truman's research is directed towards understanding both external (e.g. circadian rhythms) factors and internal (e.g. steroid and peptide hormones) factors that influence the central nervous system to regulate behavior. Using a relatively simple invertebrate model system, he is unraveling the mechanisms by which ecdysteroids, a class of steroid hormones, affect the release of eclosion hormone, a neuropeptide, to orchestrate changes in behavior. Dr. Truman has identified four neurons that are responsible for all of the eclosion hormone found in the central nervous system. He will now focus on the cellular properties of these neurons. Using state of the art electrophysiological and anatomical techniques, Dr Truman will define the mechanisms that control the release of this peptide, and then determine how it acts on the central nervous system to evoke the stereotyped behavior changes. In addition, he will employ a different invertebrate model system to examine the importance of circadian control in controlling behavior. The results from this research will provide novel insights into the relationship between the neuroendocrine system and behavior. These data serve as the foundation for the development and application of practical procedures in controlling agricultural and medical insect pests.

为了适应，动物的行为必须根据有机体的生理或发育状态而改变。Truman博士的研究方向是了解影响中枢神经系统调节行为的外部因素（如昼夜节律）和内部因素（如类固醇和肽激素）。利用一个相对简单的无脊椎动物模型系统，他揭示了蜕皮激素（一类类固醇激素）影响羽化激素（一种神经肽）的释放，从而协调行为变化的机制。楚门博士发现了四个神经元它们负责中枢神经系统中所有的羽化激素。他现在将重点研究这些神经元的细胞特性。使用最先进的电生理学和解剖学技术，Truman博士将确定控制这种肽释放的机制，然后确定它如何作用于中枢神经系统以引起刻板行为的改变。此外，他将采用不同的无脊椎动物模型系统来检验昼夜节律控制在控制行为中的重要性。这项研究的结果将为神经内分泌系统和行为之间的关系提供新的见解。这些数据为制定和应用控制农业和医疗害虫的实际程序奠定了基础。