Allene Directed Asymmetric Synthesis

丙二烯定向不对称合成

• 批准号: 9220166
• 负责人: James Marshall
• 金额: $ 25.6万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9220166&HistoricalAwards=false
• 关键词: Allene; Directed; Asymmetric; Synthesis

The focus of this research is the preparation and synthetic use of allenylmetallic reagents of tin, boron, titanium and chromium. Particular attention will center on SE' additions to aldehydes as a route to enantioenriched propargylic and allenic carbinols. Among the issues to be addressed include: the configurational and regiochemical stability of chiral allenyl and propargyl organometallics, the stereochemistry and regiochemistry of the SE' additions of these reagents, the effect of chiral ligands on the enantioselectivity of the SE' process, and possible applications of these reagents in natural product synthesis. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. James A. Marshall of the Department of Chemistry at the University of South Carolina. Professor Marshall will focus his work on developing optically active organometallic reagents for possible use in the synthesis of a variety of natural products.

本研究的重点是制备和合成应用 锡、硼、钛的联烯基金属试剂， 铬。 特别关注的焦点将集中在SE的新增内容上， 醛作为对映体富集的炔丙基和丙二烯的途径 甲醇需要解决的问题包括： 手性联烯基构型和区域化学稳定性 和炔丙基有机金属化合物，立体化学和 这些试剂的SE'加成的区域化学， 手性配体对SE'对映选择性的影响 过程，以及这些试剂在自然界中的可能应用 产物合成 %%% 有了这个更新奖，合成有机计划是 支持James A.马歇尔 南卡罗来纳州大学化学系。 马歇尔教授将把他的工作重点放在光学发展上 可能用于制备有机金属化合物的活性有机金属试剂 合成多种天然产物。