Allene Directed Asymmetric Synthesis

本研究的重点是锡、硼、钛、铬等烯基金属试剂的制备与合成。特别关注的是SE在醛上的添加，作为一种富集对映体丙炔醇和丙烯醇的途径。需要解决的问题包括：手性烯丙基和丙炔基有机金属的构型和区域化学稳定性，这些试剂的SE‘加成物的立体化学和区域化学，手性配体对SE’过程对映选择性的影响，以及这些试剂在天然产物合成中的可能应用。有了这个更新奖，合成有机项目支持了南卡罗来纳大学化学系的詹姆斯·a·马歇尔博士的研究。马歇尔教授将专注于开发光学活性有机金属试剂，以用于合成各种天然产物。

The focus of this research is the preparation and synthetic use of allenylmetallic reagents of tin, boron, titanium and chromium. Particular attention will center on SE' additions to aldehydes as a route to enantioenriched propargylic and allenic carbinols. Among the issues to be addressed include: the configurational and regiochemical stability of chiral allenyl and propargyl organometallics, the stereochemistry and regiochemistry of the SE' additions of these reagents, the effect of chiral ligands on the enantioselectivity of the SE' process, and possible applications of these reagents in natural product synthesis. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. James A. Marshall of the Department of Chemistry at the University of South Carolina. Professor Marshall will focus his work on developing optically active organometallic reagents for possible use in the synthesis of a variety of natural products.