Allene Directed Asymmetric Synthesis

丙二烯定向不对称合成

• 批准号: 9525974
• 负责人: James Marshall
• 金额: $ 44.87万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-01-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9525974&HistoricalAwards=false
• 关键词: Allene; Directed; Asymmetric; Synthesis

The focus of this research will be the development of synthetic methodology using chiral allenylmetallic reagents of tin, boron, titanium, chromium and palladium. Particular attention will be placed on electrophilic substitution additions to aldehydes as a route to enantioenriched propargylic and allenic carbinols. Elaboration of the carbinols will permit the synthesis of subunits of molecules that have important biological properties. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. James A. Marshall of the Department of Chemistry at the University of Virginia. Professor Marshall will focus his work on the development of methods for the preparation of alcohols, specifically allenylcarbinols and homopropargylic alcohols, that can serve as subunits for the construction of molecules having interesting biological properties.

本研究的重点将是开发合成的 使用锡，硼， 钛、铬和钯。 将特别注意 对醛的亲电取代加成作为一种途径， 对映体富集的炔丙醇和丙二烯甲醇。 拟订 甲醇将允许合成分子的亚单位， 重要的生物学特性。 有了这个更新奖，合成 有机计划是支持博士詹姆斯A。马歇尔 弗吉尼亚大学化学系。 教授 马歇尔将把工作重点放在发展的方法， 制备醇，特别是丙二烯基甲醇， 高炔丙醇，其可以作为构建 具有有趣生物学特性的分子。