Biosynthesis and Function of Camalexin, the Arabidopsis Phytoalexin

拟南芥植物抗毒素 Camalexin 的生物合成和功能

基本信息

  • 批准号:
    9220912
  • 负责人:
  • 金额:
    $ 19.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    1993
  • 资助国家:
    美国
  • 起止时间:
    1993-05-15 至 1997-10-31
  • 项目状态:
    已结题

项目摘要

Plants respond to inoculation with pathogens with a range of defense-associated responses, which can include the accumulation of anti-microbial, low molecular weight compounds, termed phytoalexins. The significance of any one defense-associated response in disease resistance is unknown in most host/pathogen systems. Arabidopsis thaliana accumulates the toxic metabolite 3- thiazol-2'-yl-indole after inoculation with the bacterial pathogen Pseudomonas syringae pv. syringae. This compound, which has been given the trivial name camalexin, fits the classic definition of a phytoalexin. To determine the camalexin biosynthetic pathway and to address the role of camalexin in disease resistance, mutants unable to accumulate camalexin will be isolated. Arabidopsis is ideally suited for the isolation and genetic characterization of mutants. Both feeding studies with radiolabeled precursors and analyses of camalexin-deficient mutants will help construct a biosynthetic pathway for this secondary metabolite. To evaluate the role of camalexin in limiting pathogen growth in vivo disease development in one well-defined camalexin mutant will be compared to that occurring in wild-type plants. With these results, it will be possible to formulate a broad statement about the relative role of phytoalexins in resistance to both fungal and bacterial diseases of cruciferous plants.
植物对接种病原体有一系列防御相关的反应,包括抗微生物、低分子量化合物的积累,称为植物抗菌素。在大多数宿主/病原体系统中,任何一种防御相关反应在抗病中的意义都是未知的。拟南芥在接种丁香假单胞菌后积累了有毒代谢物3-噻唑-2'-酰基吲哚。两。这种化合物,被赋予了一个不起眼的名字,camalexin,符合植物抗菌素的经典定义。为了确定camalexin的生物合成途径并确定camalexin在抗病中的作用,将分离无法积累camalexin的突变体。拟南芥非常适合突变体的分离和遗传表征。放射性标记前体的饲养研究和camalexin缺陷突变体的分析将有助于构建这种次生代谢物的生物合成途径。为了评估camalexin在体内限制病原体生长的作用,将在一个明确定义的camalexin突变体中与野生型植物中发生的疾病发展进行比较。有了这些结果,将有可能对植物抗菌素在十字花科植物抗真菌和细菌疾病中的相对作用形成一个广泛的陈述。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Raymond Hammerschmidt其他文献

A Coordinated Effort to Manage Soybean Rust in North America: A Success Story in Soybean Disease Monitoring.
北美大豆锈病管理的协调努力:大豆病害监测的成功案例。
  • DOI:
    10.1094/pdis-02-14-0121-fe
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
    E. Sikora;T. Allen;K. Wise;Gary C. Bergstrom;Carl A. Bradley;Jason P. Bond;D. Brown;M. Chilvers;J. Damicone;Erick D. DeWolf;A. Dorrance;N. Dufault;P. Esker;T. Faske;L. Giesler;N. Goldberg;J. Golod;I. G. Gómez;Craig R. Grau;A. Grybauskas;G. Franc;Raymond Hammerschmidt;Glen L. Hartman;R. A. Henn;D. Hershman;C. Hollier;T. Isakeit;S. Isard;Barry J. Jacobsen;Douglas J. Jardine;R. Kemerait;S. Koenning;M. Langham;D. Malvick;S. Markell;J. Marois;S. Monfort;D. Mueller;J. D. Mueller;R. Mulrooney;M. Newman;L. Osborne;G. B. Padgett;B. Ruden;J. Rupe;R. Schneider;H. Schwartz;Gregory Shaner;Shree P. Singh;E. Stromberg;L. Sweets;A. Tenuta;S. Vaiciunas;Xiao;H. Young;J. Zidek
  • 通讯作者:
    J. Zidek
Evaluation of the susceptibility of Prunus rootstock genotypes to Armillaria and Desarmillaria species
  • DOI:
    10.1007/s10658-020-02065-y
  • 发表时间:
    2020-07-04
  • 期刊:
  • 影响因子:
    1.900
  • 作者:
    Pratima Devkota;Amy Iezzoni;Ksenija Gasic;Gregory Reighard;Raymond Hammerschmidt
  • 通讯作者:
    Raymond Hammerschmidt
Origin of the Thiazole Ring of Camalexin, a Phytoalexin from Arabidopsis thaliana
拟南芥植物抗毒素 Camalexin 噻唑环的起源
  • DOI:
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Michael Zook;Raymond Hammerschmidt
  • 通讯作者:
    Raymond Hammerschmidt
Antifungal activity in winter squash fruit peel in relation to age related resistance to <em>Phytophthora capsici</em>
  • DOI:
    10.1016/j.pmpp.2021.101603
  • 发表时间:
    2021-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Safa A. Alzohairy;Raymond Hammerschmidt;Mary K. Hausbeck
  • 通讯作者:
    Mary K. Hausbeck
Abstracts of papers presented at the 81st annual meeting of The Potato Association of America Charlottetown, P.E.I., Canada August 3 – 7, 1997
  • DOI:
    10.1007/bf02852782
  • 发表时间:
    1997-11-01
  • 期刊:
  • 影响因子:
    1.800
  • 作者:
    S. T. Ali-Khan;C. Hetner;L. Ladislav;V. Currie;Walter J. Arsenault;A. Naseer Aziz;Janet E. A. Seabrook;George C. C. Tai;J. B. Bamberg;Alfonso H. del Rio;Max Martin;J. B. Bamberg;D. J. Ormrod;W. E. Fry;K. B. Barrett;P. Nolte;W. B. Jones;M. A. Bateman;M. C. Bertram;L. L. Nolte;Melissa C. Bertram;John Ojala;Geoffrey A. Barrall;James T. Blankemeyer;Misty L. McWilliams;Mendel Friedman;Gilles Boiteau;Tatiana Boluarte;Richard E. Veilleux;C. R. Brown;B. Schuck-Ennis;C. P. Yang;H. Mojtahedi;G. S. Santo;Athyna N. Cambouris;Michel C. Nolin;Régis R. Simard;Eduard Cani;Varda Ashkenazi;Jossi Hillel;Richard E. Veilleux;M. R. Cappaert;M. L. Powelson;D. I. Inglis;M. R. Cappaert;M. L. Powelson;Yu-Kuang Chen;John B. Bamberg;Jiwan P. Palta;B. J. Christ;K. G. Haynes;Robert R. Coltman;Thomas L. German;Dennis Corsini;Gale Kleinkopf;Tina Brandt;Rebecca Outright;Richard E. Veilleux;H. Dan;A. Stankiewicz;S. T. Ali-Khan;J. Robb;Robert D. Davidson;D. S. Douches;W. W. Kirk;J. B. Bamberg;Linnell M. Edwards;Suzanne M. Emery;Donald E. Halseth;Elmer E. Ewing;Ivan Simko;Peter J. Davies;Sydney Fernando;Jeffrey McMorran;Alvin Mosley;George Clough;David Finnan;Eric Allen;Caragh B. Fitzgerald;Gregory A. Porter;M. Susan Erich;R. W. Goth;K. G. Haynes;E. J. Grafius;D. Mota-Sanchez;B. A. Bishop;M. E. Whalon;Horia Groza;Bryan Bowen;Jiming Jiang;Horia Groza;Robert Coltman;Christopher C. Gunter;Jiwan P. Palta;Christopher C. Gunter;Jiwan P. Palta;A. J. Hamernik;R. E. Hanneman;Philip B. Hamm;Russell E. Ingham;Joy R. Jaeger;R. E. Hanneman;K. G. Haynes;D. H. Lambert;B. J. Christ;D. P. Weingartner;D. S. Douches;J. E. Backlund;G. Secor;W. Fry;W. Stevenson;J. P. Helgeson;G. T. Haberlach;J. M. McGrath;J. A. Raasch;S. K. Naess;S. M. Wielgus;A. Hernández;H. Lozoya-Saldaña;T. Zavala;Brian L. Honess;George C. C. Tai;C. Wayne Honeycutt;Becky R. Hughes;Candy N. F. Keith;D. A. Inglis;B. Gundersen;M. L. Powelson;M. R. Cappaert;D. Inglis;B. Gundersen;R. Thornton;Shelley Jansky;Doug Rouse;Alexander Johnson;Suzanne Piovano;Vidya Ravichandran;Sirasak Teparkum;Eduard Chani;Richard E. Veilleux;W. B. Jones;D. W. Hempstead;J. B. Scott;Willy Kalt;Robert Prange;Barbara Daniels-Lake;John Walsh;Paul Dean;Robert Coffin;Robyne Page;L. M. Kawchuk;H. DeJong;V. J. Burns;J. Kimpinski;H. W. Platt;William Kirk;Brendan A. Niemira;Brian Kitchen;Jeffery Stein;Raymond Hammerschmidt;Stanley P. Kowalski;John M. Domek;Frances G. Perez;Lind L. Sanford;Kenneth L. Deahl;Stanley P. Kowalski;G. Craig Yencho;Ruth S. Kobayashi;Frances G. Perez;Stephen L. Sinden;Kenneth L. Deahl;David W. Laird;Albert B. Bassi;Allison Tally;Dave Lambert;Ann Currier;Modesto Olanya;W. Li;D. S. Douches;W. Pett;J. Coombs;K. Zarka;E. Grafius;Rosemary Loria;Barbara A. Fry;Raghida A. Bukhalid;Elizabeth A. Grace;Alan R. Langille;Yu Lan;A. F. Reeves;Stephen L. Love;Bruce K. Werner;Joseph J. Pavek;H. Lozoya-Saldaña;A. Hernãndez;H. Lozova-Saldaña;A. Hern↭dez;R. Flores;J. Bamberg;R. L. Ludy;M. L. Powelson;Edward C. Lulai;Manrique Klinge;Stephen L. Lovev Kurt;Jack Brown;Medina Marco;H. W. Platt;R. D. Peters;Jenifer Huang McBeath;J. Miller;Douglas C. Creighton;Jeannine P. Millerv Scheuring;George C. J. Fernandez;Dallice Mills;Brian W. Russell;J. Mozafari;D. J. Wolyn;S. T. Ali-Khan;S. I. Mpofu;R. Hall;C. Mundy;N. G. Creamer;C. R. Crozier;R. D. Morse;George Newberry;Robert Thornton;Brendan A. Niemira;William Kirk;David Douches;Raymond Hammerschmidt;P. Nolte;M. K. Thornton;S. L. Love;P. H. Berger;J. L. Whitworth;R. Davidson;Richard Novy;Craig Longtine;Solanum Etuberosum;Claudia Olivier;Eduardo S. G. Mizubuti;Donald E. Halseth;Rosemary Loria;Nora L. Olsen;Robert E. Thornton;R. L. Parks;M. L. Powelson;M. R. Cappaert;K. B. Johnson;Joseph J. Pavek;Dennis L. Corsini;Sridevi Pavuluri;T. P. Freeman;D. Baer;N. C. Gudmestad;Yvan Pelletier;Iris E. Peralta;Harvey Ballard;David M. Spooner;R. D. Peters;H. W. (Bud) Platt;Robert Hall;A. Driscoll;A. MacPhail;S. Jenkins;E. Connors;M. Medina;V. MacLean;Maxwell Philip;H. W. Platt;R. Nazar;J. Robb;V. MacLean;Omaira Pineda;Robert L. Plaisted;Steven D. Tanksley;Omaira Pineda;Robert L. Plaisted;Steven D. Tanksley;H. W. Platt;M. Medina;S. Perley;J. Walsh;Gregory A. Porter;Jonathan A. Sisson;Gregory A. Porter;Jonathan A. Sisson;R. J. Power;R. A. Hamlen;R. M. Gimenez;R. Iruegas;Robert Prange;Willy Kalt;Barbara Daniels-Lake;Chiam Liew;John Walsh;Paul Dean;Robert Coffin;Robyne Page;M. Ramon;Felix C. Serquen;R. E. Hanneman;Bruce Riggle;Ron Schafer;Alfonso H. del Rio;J. B. Bamberg;R. Romain;R. Lambert;R. Michaud;C. Lapointe;Catherine M. Ronning;Lind L. Sanford;John R. Stommel;Frances G. Perez;Kenneth L. Deahl;J. Brian Sanderson;M. R. Carter;H. W. Johnston;D. A. Holmstrom;L. L. Sanford;S. Kowalski;K. L. Deahl;C. Ronning;D. A. Schisler;G. Kleinkopf;P. J. Slininger;R. J. Bothast;R. C. Ostrowski;Janet E. A. Seabrook;L. Katheryn Douglass;Mohamed, R. B. Sedegui;A. L. Morehart Carroll;D. P. Whittington;R. P. Mullroony;Felix C. Serquen;Robert E. Hanneman;Régis R. Simard;Athyna Cambouris;Jean Lafond;A. Tyouss;Mathuresh Singh;Rudra P. Singh;Rudra P. Singh;P. J. Slininger;D. A. Schisler;K. D. Burkhead;R. C. Ostrowski;R. J. Bothast;Junqi Song;Jiming Jiang;Jose A. Souza-Dias;P. Russo de Caram;J. A. Betti;L. Miller;S. A. Slack;Jose A. Souza-Dias;de Caram;J. F. Tristao;Joseph R. Sowokinos;Mark Stalham;Anton Rosenfeld;Jeff Stewart;Antony V. Sturz;Brian G. Matheson;Sirasak Teparkum;Richard E. Veilleux;Asunta Thompson-Johns;Robert D. Davidson;George H. Timm;Robert E. Thornton;Peter Van Hest;J. J. van der Merwe;Michael E. Vayda;James K. Morelli;Kathryn M. Englehart;Sandra E. Vega;John B. Bamberg;Jiwan P. Palta;John Walsh;R. Larry Peterson;Lewis Melville;L. Wang;M. K. Pritchard;L. Wang;M. K. Pritchard;A. Westedt;D. S. Douches;E. Grafius;D. T. Westermann;J. R. Davis;D. O. Everson;Richard W. Work;T. M. Work;A. A. Bushway;Therese M. Work;Alvin A. Reeves;Wan-Chin Yu;Peter J. Joyce;Douglas C. Cameron;Brent H. McCown;Richard E. Veilleux
  • 通讯作者:
    Richard E. Veilleux

Raymond Hammerschmidt的其他文献

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{{ truncateString('Raymond Hammerschmidt', 18)}}的其他基金

Controlling Sesquiterpene Synthase Gene Expression in Potato
控制马铃薯中的倍半萜合酶基因表达
  • 批准号:
    9603168
  • 财政年份:
    1997
  • 资助金额:
    $ 19.99万
  • 项目类别:
    Continuing Grant

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