Tyrosine Hydroxylase in Primary Somatosensory Neurons

初级体感神经元中的酪氨酸羟化酶

• 批准号: 9221136
• 负责人: Kim Seroogy
• 金额: $ 22.32万
• 依托单位: University of Kentucky Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-15 至 1997-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9221136&HistoricalAwards=false
• 关键词: Tyrosine; Hydroxylase; Primary; Somatosensory; Neurons

Primary sensory neurons located along the length of the spinal cord in structures known as spinal ganglia convey information about the body (somatosensory information; e.g. pain, temperature) to the central nervous system. Defining the anatomical, biochemical, and molecular characteristics of these sensory nerve cells is prerequisite to determining their function. Dr. Seroogy has recently discovered that substantial subpopulations of spinal ganglion cells contain the biosynthetic machinery for an enzyme called tyrosine hydroxylase, an enzyme crucial for the synthesis of a class of chemical messengers called catecholamines. This finding raises the possibility that catecholamines play a role in the transfer and coding of sensory information from the body. The primary goals of the proposed research are to thoroughly characterize the organization of tyrosine hydroxylase (and catecholamines) within spinal ganglia and to determine the specific parts of the body that may be associated with catecholamine signalling. Dr. Seroogy will accomplish this by using molecular biological and neuroanatomical techniques. The results of these studies will add significantly to our understanding of the functional organization of catecholamines in spinal ganglia and will serve as the basis for future correlations with physiological studies in order to understand the involvement of catecholamines in transmitting sensory information.

初级感觉神经元沿着脊髓长度分布 在称为脊神经节的结构中， 身体（躯体感觉信息;例如疼痛，温度） 中枢神经系统 定义解剖学，生物化学， 这些感觉神经细胞的分子特征是 这是确定其功能的先决条件。 血清学博士 最近发现，大量的脊椎动物亚群 神经节细胞含有一种酶的生物合成机制 称为酪氨酸羟化酶，一种对合成 一种叫做儿茶酚胺的化学信使 这一发现 提出了一种可能性，即儿茶酚胺在 传递和编码来自身体的感觉信息。 的 拟议研究的主要目标是彻底 表征酪氨酸羟化酶的组织（和 和确定特定的 可能与儿茶酚胺有关的身体部位 信号装置. 血清学博士将通过使用分子 生物学和神经解剖学技术。 的结果予以 研究将大大增加我们对 脊髓神经节中的儿茶酚胺功能组织， 将作为未来与生理相关性的基础， 研究，以了解参与的儿茶酚胺， 传递感官信息