GABA - Acetylcholine Interactions and Memory

GABA - 乙酰胆碱相互作用和记忆

• 批准号: 9222097
• 负责人: Thomas Walsh
• 金额: $ 25.35万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1996-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9222097&HistoricalAwards=false
• 关键词: GABA; Acetylcholine; Interactions; Memory

How do we construct maps of the real world in our brain? Apparently there is a structure called the hippocampus that contains a spatial map that is laid down through experience. Dr. Walsh has devised a novel behavioral test to assess how various chemical inputs affect the behavioral function of this structure. With this NSF grant he will manipulate the chemical environment of the cells that provide major inputs to the hippocampus. By measuring the number and types of errors made in a spatial maze after each manipulation he will be able to determine whether his chemical manipulations have improved or interfered with hippocampal function. The results of these experiments will improve our understanding of the neurobiological foundations of learning and memory. The future applications will include drugs that can be used to improve memory or, alternatively, reduce the influence of unwanted, intrusive memories.***//

我们如何在大脑中构建真实的世界的地图？ 显然有一种叫做海马体的结构， 包含了一张通过经验绘制的空间地图。 博士 沃尔什设计了一种新颖的行为测试， 化学输入影响该结构的行为功能。 有了这个NSF的资助，他将操纵化学环境， 这些细胞为海马体提供主要的输入。 通过 测量空间迷宫中错误的数量和类型 每次操作后，他将能够确定他的 化学处理改善或干扰了海马 功能 这些实验的结果将提高我们的 了解学习的神经生物学基础， 记忆 未来的应用将包括药物， 用于改善记忆力，或者减少 不必要的，侵入性的记忆。*//