GABA - Acetylcholine Interactions and Memory

我们如何在大脑中构建真实世界的地图？显然，有一种叫做海马体的结构，它包含了一张通过经验绘制的空间地图。沃尔什博士设计了一种新的行为测试，以评估不同的化学物质输入如何影响这种结构的行为功能。有了这笔NSF拨款，他将操纵为海马体提供主要输入的细胞的化学环境。通过测量每次操作后在空间迷宫中犯下的错误的数量和类型，他将能够确定他的化学操作是否改善了或干扰了海马体功能。这些实验的结果将提高我们对学习和记忆的神经生物学基础的理解。未来的应用将包括可以用来改善记忆或减少不想要的侵入性记忆的影响的药物。*//

How do we construct maps of the real world in our brain? Apparently there is a structure called the hippocampus that contains a spatial map that is laid down through experience. Dr. Walsh has devised a novel behavioral test to assess how various chemical inputs affect the behavioral function of this structure. With this NSF grant he will manipulate the chemical environment of the cells that provide major inputs to the hippocampus. By measuring the number and types of errors made in a spatial maze after each manipulation he will be able to determine whether his chemical manipulations have improved or interfered with hippocampal function. The results of these experiments will improve our understanding of the neurobiological foundations of learning and memory. The future applications will include drugs that can be used to improve memory or, alternatively, reduce the influence of unwanted, intrusive memories.***//