The dynamic interplay between the matrix and cell fate in developing heart

心脏发育过程中基质与细胞命运之间的动态相互作用

• 批准号: DE230101315
• 负责人: Dr Victoria Garside
• 金额: $ 32.49万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101315
• 关键词: dynamic; interplay; between; matrix; cell

Malformations in the developing heart can lead to catastrophic defects and embryonic loss. The valves play a critical role in blood flow regulation and are made of a stratified matrix that is laid down early in development. This project aims to determine how the cellular fate of the early valve cells establish the layered matrix and in turn how the matrix can influence cell fate by utilising a multi-omics approach to identify unique cell populations and integrate transcriptional and protein changes during matrix disruption. This project expects to generate fundamental knowledge on how matrix structure can influence cell fate in the valves and will advance Australia's knowledge base and research capabilities in developmental biology.

发育中的心脏畸形会导致灾难性的缺陷和胚胎丢失。瓣膜在血流调节中起着关键作用，由发育早期形成的分层基质组成。该项目旨在确定早期瓣膜细胞的细胞命运如何建立分层基质，以及基质如何通过利用多组学方法来识别独特的细胞群并整合基质破坏期间的转录和蛋白质变化来影响细胞命运。该项目预计将产生关于基质结构如何影响瓣膜细胞命运的基础知识，并将推进澳大利亚在发育生物学方面的知识基础和研究能力。