NSF Young Investigator/Metallobiochemistry of Nucleic Acids and of Redox Proteins

NSF 青年研究员/核酸和氧化还原蛋白的金属生物化学

• 批准号: 9258168
• 负责人: Charles Hille
• 金额: --
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-15 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9258168&HistoricalAwards=false
• 关键词: NSF; Young; Investigator; Metallobiochemistry; Nucleic

Dr. James A. Cowan has been selected as a National Science Foundation 1992 Young Investigator. This five year continuing award recognizes the research and teaching achievements of new faculty members. Cowan is a member of the chemistry department at Ohio State University where he will continue to carry out research in bioinorganic chemistry, concentrating on understanding the structural requirements for the interaction of metals with nucleic acids and enzymes. His work will focus on four areas: (1) the role of the magnesium ion cofactor in polynucleotide processing enzymes; (2) sequence selective metal binding to nucleic acids; (3) metalloregulatory mechanisms for DNA-protein interactions; and (4) structural factors of protein binding to high potential iron protein. Folding and sequencing in proteins imposes specific requirements for association by a metal, but binding by a metal can also modify the protein's structure and enhance (or reduce) its enzymatic activity. Cowan will investigate these specific cases in order to understand the requirements for and consequences of metal binding to DNA and certain polynucleotides and enzymes.

James A.科万已被选为国家科学 1992年青年调查员。 这五年来， 该奖项旨在表彰新的研究和教学成就 教职员工。 科万是化学系的一员 在俄亥俄州州立大学，他将继续进行 生物无机化学研究，专注于 了解相互作用的结构要求 金属与核酸和酶的结合 他的工作将集中在 四个方面：（1）镁离子辅因子在 多核苷酸加工酶;（2）序列选择性金属 与核酸结合;（3）金属调节机制， DNA-蛋白质相互作用;（4）蛋白质的结构因素 与高电位铁蛋白结合。折叠和测序 对蛋白质的结合提出了特定的要求， 金属，但金属的结合也可以改变蛋白质的 结构化并增强（或降低）其酶活性。 科万将调查这些具体案件， 了解金属的要求和后果 与DNA、某些多核苷酸和酶结合。