Frequency-Agile Optical Imaging of the Nervous System

神经系统的捷变频光学成像

• 批准号: 9260021
• 负责人: Salvador Fernandez
• 金额: $ 5万
• 依托单位: CIENCIA INC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-15 至 1993-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9260021&HistoricalAwards=false
• 关键词: Frequency; Agile; Optical; Imaging; Nervous

Development of a novel optical imaging system for studies of the nervous system is proposed. The concept is based on the use of acousto-optic tunable filters as spectral selection elements in a confocal fluorescence microscope. In conjunction with the use of multiply labeled specimens the proposed instrument will permit investigation of neurochemistry-specific three-dimensional architecture of nervous tissue. The rapid bandpass switching time of the acousto-optic devices will permit dynamic studies to be performed on a time scale commensurate with the electrical signaling of neurons.

提出了一种用于神经系统研究的新型光学成像系统的开发。这一概念是基于使用声光可调谐滤光器作为共聚焦荧光显微镜的光谱选择元件。结合多个标记样本的使用，建议的仪器将允许研究神经组织的神经化学特定的三维结构。声光器件的快速带通切换时间将允许在与神经元电信号相称的时间尺度上进行动态研究。