Raman Spectrometer for in-vivo Tissue Analysis

这个小型企业创新研究第一阶段项目是为了开发一种紧凑、坚固耐用的光纤拉曼光谱仪系统，适合在临床环境中进行实时、活体的组织分析。基于激光的光谱方法，如荧光光谱和拉曼光谱，在根据化学成分识别组织和评估组织的健康状态方面显示出巨大的前景。与光纤相结合，这些方法提供了在体内进行组织化学分析的非凡潜力。在这些强大的新诊断方法能够在临床环境中作为实用工具实施之前，需要解决一些仪器问题。特别是，目前的实验室研究仪器必须改装成坚固、低成本、易于使用、紧凑的设备，适合在临床环境中部署，并由临床人员可靠地操作。这项提议为解决这一问题提供了一种创新的方法。

This Small Business Innovation Research Phase I project is for development of a compact, rugged, fiber-optic Raman spectrometer system suitable for performing real-time, in vivo, tissue analysis in a clinical setting. Tissue characterization by laser-based spectroscopic methods, such as fluorescence and Raman spectroscopy is showing significant promise for identification of tissues on the basis of chemical composition and for evaluating the health status of tissues. Coupled with fiber-optics, these methods offer the extraordinary potential of performing tissue chemical analysis in vivo. Before these powerful new diagnostic methodologies can be implemented as practical tools in a clinical setting, a number of instrumentation problems need to be resolved. In particular, current laboratory research instruments must be converted into rugged, low-cost, easy-to-use, compact units suitable for deployment in a clinical setting and reliable operation by clinical personnel. This proposal offers an innovative approach to solving this problem.