Raman Spectrometer for in-vivo Tissue Analysis

该小型企业创新研究I期项目旨在开发一种紧凑、坚固的光纤拉曼光谱仪系统，适用于在临床环境中进行实时体内组织分析。通过基于激光的光谱方法（例如荧光和拉曼光谱）进行的组织表征显示出基于化学组成的组织识别和用于评估组织的健康状态的显著前景。再加上光纤，这些方法提供了在体内进行组织化学分析的非凡潜力。在这些功能强大的新诊断方法可以作为临床环境中的实用工具实施之前，需要解决一些仪器问题。特别是，目前的实验室研究仪器必须转换成坚固的，低成本的，易于使用的，紧凑的单元，适用于部署在临床设置和可靠的操作，由临床人员。这一建议为解决这一问题提供了一种创新的方法。

This Small Business Innovation Research Phase I project is for development of a compact, rugged, fiber-optic Raman spectrometer system suitable for performing real-time, in vivo, tissue analysis in a clinical setting. Tissue characterization by laser-based spectroscopic methods, such as fluorescence and Raman spectroscopy is showing significant promise for identification of tissues on the basis of chemical composition and for evaluating the health status of tissues. Coupled with fiber-optics, these methods offer the extraordinary potential of performing tissue chemical analysis in vivo. Before these powerful new diagnostic methodologies can be implemented as practical tools in a clinical setting, a number of instrumentation problems need to be resolved. In particular, current laboratory research instruments must be converted into rugged, low-cost, easy-to-use, compact units suitable for deployment in a clinical setting and reliable operation by clinical personnel. This proposal offers an innovative approach to solving this problem.