Studies of Receptor-Based Chemical Sensors

基于受体的化学传感器的研究

• 批准号: 9300694
• 负责人: Frank Bright
• 金额: $ 22.9万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 1996-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9300694&HistoricalAwards=false
• 关键词: Studies; Receptor; Based; Chemical; Sensors

This project is in the general area of analytical and surface chemistry and in the subfield of chemical sensors. During the tenure of this three-year continuing grant, Professor Bright and his students will build upon results derived from previous studies supported under NSF grant CHE-8921517 and employ excited state fluorescence decay kinetics to study the immobilization of active antibody fragments and their interaction with a soluble antigen. The overall goal of this research is directed toward improving our understanding of biological and synthetic chemical recognition elements (receptors) immobilized at an interface. %%% This research will yield fundamental information on the thermodynamics and dynamics of surface-immobilized receptors (artificial and biochemical) thereby providing valuable insights to guide the development of interfaces suitable for chemical sensing in complex milieu and enable the rational design of a variety of technologically important receptor-based sensing devices.

这个项目是在一般地区的分析和表面 化学和化学传感器领域。 期间 在这三年的持续资助下，Bright教授和 他的学生们将在以前研究成果的基础上 在NSF资助CHE-8921517下支持，并采用激发态 荧光衰减动力学研究固定化活性 抗体片段及其与可溶性抗原的相互作用。 这项研究的总体目标是提高我们的 了解生物和合成化学识别 固定在界面上的元素（受体）。 %%% 这项研究将产生关于 表面固定受体的热力学和动力学 （人工和生物化学），从而提供有价值的见解 指导开发适合化学品的接口， 传感在复杂的环境中，并使合理的设计， 各种技术上重要的基于受体的传感 装置.