Bioprocess Integration for Enzyme - Catalyzed Syntheses

酶催化合成的生物过程集成

• 批准号: 9301447
• 负责人: Giorgio Carta
• 金额: $ 29.37万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-15 至 1998-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9301447&HistoricalAwards=false
• 关键词: Bioprocess; Integration; Enzyme; Catalyzed; Syntheses

9301447 Carta This research project is to investigate chemical syntheses using immobilized enzymes in organic media. A major goal is to develop a bioreactor system which can be used efficiently for large-volume production. The proposed bioreactor is an integrated system in which enzymatic conversion and separation occur simultaneously. As a result, the conversion can have values greater than the limits imposed by thermodynamic equilibrium in conventional reactors. Also, the nearly continuous and simultaneous removal of water, which occurs with the proposed reactor system, should reduce the inhibitory and denaturing effects that water has on these enzyme- catalyzed condensation reactions. In addition, mathematical models will be used to extend the reactor system to other reactions.

9301447 Carta 该研究项目旨在研究在有机介质中使用固定化酶进行化学合成。 一个主要目标是开发一种可有效用于大批量生产的生物反应器系统。 所提出的生物反应器是一个集成系统，其中酶促转化和分离同时发生。 因此，转化率的值可以大于常规反应器中热力学平衡所施加的限制。 此外，所提出的反应器系统几乎连续且同时去除水，应减少水对这些酶催化缩合反应的抑制和变性作用。 此外，数学模型将用于将该反应器系统扩展到其他反应。