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To examine the stress-mediated profibrotic and arrhythmic response in clinically relevant hypertrophic cardiomyopathy associated cardiac troponin-T (TNNT2) gene variants.

To examine the stress-mediated profibrotic and arrhythmic response in clinically relevant hypertrophic cardiomyopathy associated cardiac troponin-T (TNNT2) gene variants.
研究临床相关肥厚型心肌病相关心肌肌钙蛋白-T (TNNT2) 基因变异中应激介导的促纤维化和心律失常反应。
批准号：
473762
负责人：
Nagalingam Raghu Sundaresan
金额：
$9.83万
依托单位：
Simon Fraser University (Burnaby, B.C.)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-10-01 至 2025-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=473762&lang=en
关键词：
Cardiac Fibrosis Crispr Gene Editing Electrophysiology Hypertrophic Cardiomyopathy Induced Pluripotent Stem Cell-Derived Cardiomyocytes Induced Pluripotent Stem Cell-Derived Fibroblasts

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The human heart beats tirelessly to help supply oxygen-rich blood to the circulation, and the contractile proteins consisting of cardiac muscle cells facilitate this process. Hypertrophic cardiomyopathy (HCM) is a hereditary heart disease that triggers pa
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