PRF/J: Molecular Evolution in Strepsirhine Primates

这里的目的是生成和比较线粒体和 核DNA序列，以探讨克里思和模式， 链鼻灵长类中的序列进化（例如，狐猴和 懒猴）。 这项研究的主要目的是测试两个 离散假设：（a）狐猴表现出降低的分子速率 与懒猴和其他灵长类动物相比，和（B） 狐猴的转变速度更慢 如果可以证明 狐猴经历了相对于其他狐猴的分子减速 灵长类动物，这表明世代时间不是 控制灵长类动物繁殖率的主要变量 进化 降低了分子进化的整体速率 与降低的转换率同时发生， 一种可以延缓或加速总速率的机制。 大量的线粒体DNA和核DNA序列被生成 对于统一的分类学样本， 两个数据集的演化和遗传。 一项主要的研究 这种方法的优势在于分子进化现象 将在一个强大的系统发育背景下进行探索。 %%% 预计结果将有助于我们了解 链鼻狐猴的进化，更具体地说是马达加斯加狐猴， 这是对生物多样性的保护。 此外，调查结果将 影响了正在进行的关于分子钟真实性的争论。 目前的争论主要是缺乏共识， 部分原因是许多研究的系统发育基础较差。 一 研究的第三个理由是它对核武器的评估。 与线粒体核苷酸序列相比， 经常 线粒体DNA数量级和核比率的估算 差异可能会影响这些基因的系统发育效用。

The intent here is to generate and compare mitochondrial and nuclear DNA sequences in order to explore the tempo and mode of sequence evolution in strepsirhine primates (e.g., lemurs and lorises). The primary objective of this research is to test two discrete hypotheses: (a) do lemurs show a reduced rate of molecular evolution compared to lorises and other primates?, and (b) do lemurs exhibit a slower transition rate? If it can be demonstrated that lemurs have experienced a molecular slowdown relative to other primates, this would indicate that generation time isn't the principal variable responsible for controlling the rate of primate evolution. A reduced overall rate of molecular evolution coincident with a depressed transition rate would be suggestive of a mechanism whereby overall rates can be retarded or accelerated. The large number of mtDNA and nuclear DNA sequences to be generated for a uniform taxonomic sample will enable comparisons of rates of evolution and phylogenies for the two data sets. A prime research strength of this approach is that molecular evolutionary phenomena are to be explored within a robust phylogenetic context. %%% Results are expected to shed light on our understanding of strepsirhine evolution and more specifically Malagasy lemuriforms, which exemplify biological diversity. In addition findings will impact the on-going debate over the reality of a molecular clock. The lack of consensus that predominates the current controversy is partly due to the poor phylogenetic grounding of many studies. A third justification for the study is its assessment of nuclear versus mitochondrial nucleotide sequences, an approach not taken so often. Estimation of the magnitude of mtDNA and nuclear rate differentials may affect the phylogenetic utility of those genes.